Synthesis and Performance of Molecular Imprinted Polymers as Drug Release Controller

Abstract

Molecular imprinted polymers were synthesized using α-methylacrylacid as monomer, acetylsalicylic acid as template. Polyethylene glycol dimethylacrylate was taken as cross-linker. UV-Vis spectrophotometer was used to detect the drug-loading and releasing performances of these polymers. The studies showed that the imprinted polymers could load more drugs than non-imprinted polymer, and exhibited a slower drug-releasing rate than the latter at pH 7.4. The content of cross-linker had influences on drug-loading amounts. The imprinted polymer released few drugs at the buffer solution of pH 1.2.

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

“…The integration of MIPs in, or interaction of MIPs with, biological systems is perhaps the area that has drawn most attention from the scientific community at large over recent years. Two themes dominate this sector, namely the use of MIPs for drug delivery and the development of MIPs with biological function . The use of molecular imprinted materials in conjunction with ocular drug delivery is arguably the sector that has come closest to clinical use.…”

Preparation of an Electrochemical Sensor Based on Surface Molecularly Imprinted Polymers Modified Electrode and its Application in Detection of Nitrocellulose

“…MIPs are prepared through both covalent and non-covalent interactions of functional monomers with the molecule of interest or its analogues, acting as a template. MIPs have a good stability, high affinity and selectivity that are widely used in chiral substances resolution [18], bionic-sensors [19], solid-phase extraction [20], enzyme catalysis simulation [21] and drug controlled release [22]. MIPs allow the formation of molecules with recognition sites specific for a target analyte producing a substance specific coating which may then be incorporated onto a sensing platform.…”