Synthesis and pharmacological properties of N‐substituted‐N′‐(4,6‐dimethylpyrimidin‐2‐yl)‐thiourea derivatives and related fused heterocyclic compounds

Abstract

C NMR, mass spectrometry, and the elemental analysis. The crystal structures were determined from single crystal X-ray diffraction data. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compounds 3d and 3a exhibited the greatest antimicrobial activity.

1-(4,6-Dimethylpyrimidin-2-yl)thiourea

“…The crystal structure of the title compound is a byproduct of the reaction of 1-(4,6-dimethylpyrimidin-2-yl)-3-(3,5-dinitrophenyl)thiourea with a copper acetate salt. It is related to our previous studies on the structural chemistry of heterocyclic compounds containing an N-substituted thiourea (Saeed et al, 2010a(Saeed et al, , 2010b(Saeed et al, , 2011. Herein, as a continuation of these studies, the structure of the title compound, (I), C 7 H 10 N 4 S, is described.…”

A co-crystal of 3-(3,5-dinitrobenzoyl)-1,1-dimethylthiourea andN,N-dimethyl-3,5-dinitrobenzamide

“…The crystal structure of the 1:1 adduct of 3-(3,5-dinitro-benzoyl)-1,1-dimethyl-thiourea and N,N-dimethyl-3,5-dinitrobenzamide is reported. It is related to our previous studies on the structural chemistry of heterocyclic compounds containing an N-substituted thiourea (Saeed et al, 2010a(Saeed et al, , 2010b(Saeed et al, , 2011 and amide (Saeed et al, 2012). Herein, as a continuation of these studies, the structure of the title compound, (I), is described.…”

1-(4,6-Dimethylpyrimidin-2-yl)-3-(3,5-dinitrobenzoyl)thiourea monohydrate

“…The background to this study has been described in our previous work on the structural chemistry of N,N′-disubstituted thiourea (Saeed et al, 2011). In continuation of our studies, the crystal structure of the title compound, is presented in this paper.…”