Synthesis and Physicochemical and Biological Properties of 8-Amino-Substituted 7-(2-Aryl-2-Oxoethyl)Xanthines

Romanenko, N. I.; Назаренко, М. В.; Kornienko, V. I.; Samura, B. A.; Пахомова, О. А.

doi:10.1007/s11094-014-1142-3

Cited by 3 publications

(1 citation statement)

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“…Interest to compounds containing the purine cycle is due by a wide range of their biological activity. Thus, purine derivatives have anticancer [1], antiviral [2], anti-in ammatory [3], antimicrobial and antituberculous [4][5][6] and other activities. Adenine is a nitrogenous base, an amino derivative of purine (6-aminopurine), which is part of many compounds vital for living organisms, such as: adenosine, adenosine phosphatases, adenosine phosphoric acids, nucleic acids, adenine nucleotides etc.…”

Section: Introductionmentioning

confidence: 99%

Features of the Сrystal Structure of Benzyl Derivatives of Triacanthine. Effect of Weak Interactions on the Formation of Stable Channel Type Solvates

Turgunov

Izotova

Ташходжаев

et al. 2023

Preprint

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The alkaloid triacanthine was isolated from Gleditschia triacanthos and its di- and tribenzyl derivatives were synthesized. Both compounds are crystallized in the R-3 space group with same unit cell parameters. A channel is formed in the crystals, in which water molecules with large thermal parameters located on the c axis on H-bonds distances. In the dibenzyl derivative of triacanthine, the prenyl group is disordered in two positions in a ratio of 0.65:0.35, which makes it possible to fill voids in the crystal packing. The Hirshfeld surface analysis indicates that the most important contributions to the crystal packing are from H…H (about 57.9% and 51.4% for di- and tribenzyl derivatives respectively) and H…C/C…H (around 14.9% and 19.2%) interactions.

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