Synthesis and Pore Structure of Monolithic Polymeric Sorbents

Khimich, G. N.; Rakhmatullina, Ekaterina; Slabospitskaya, M. Yu.; Tennikova, Tatiana

doi:10.1007/s11167-005-0354-4

Cited by 10 publications

(5 citation statements)

References 19 publications

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“…The main factors affecting photopolymerization are the light intensity, as well as nature and concentration of the initiator. Khimich et al [67] investigated the preparation of poly(GMA-co-EDMA) monoliths using photoinitiated polymerization with (Darokur-1173) as initiator and cyclohexanol as a porogen. The use of 1 wt% of this initiator provided a 96% yield after 20 min of irradiation with UV light having a wavelength of 320 nm.…”

Section: Photopolymerizationmentioning

confidence: 99%

Preparation of methacrylate monoliths

Влах

Tennikova²

2007

J of Separation Science

151

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Rigid macroporous polymers developed in the early 1990s are widely used as efficient stationary phases for all types of chromatographic separations. The main advantages of so-called monolithic supports are their high hydraulic permeability and the dominance of the convection over the diffusion mechanism of mass-exchange under dynamic conditions that allow the separation to be carried out at extremely high flow rates and, consequently, during very short operation times. Among other types of macroporous polymers, the methacrylate-based monolithic materials represent the most popular and successfully explored class of sorbents. This review is an attempt to collect together the contributions of different groups working in the area of monolith preparation. Examples of different methcrylate monomers and crosslinkers, as well as porogenic solvents, including polymer ones, used in monolith preparation are discussed.

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Section: Photopolymerizationmentioning

confidence: 99%

Preparation of methacrylate monoliths

Влах

Tennikova²

2007

J of Separation Science

151

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“…As mentioned previously, the presence of a foreign solvent (1,4‐dioxane) in the polymerization mixture leads to significant changes in the process of macroporous structure formation. Earlier, in the case of the synthesis of poly(GMA‐ co ‐EDMA) monoliths by photoinitiated free‐radical polymerization, we demonstrated that the use of CyOH as the only porogen was absolutely sufficient to obtain a material with an average pore size of about 900–1000 nm 28. In contrast, in the case of the preparation of poly(HPIEAA‐ co ‐GMA‐ co ‐EDMA), the use of CyOH as the only porogen led to the formation of a monolith with an average pore size of 30 nm (sample M1).…”

Section: Resultsmentioning

confidence: 95%

“…Earlier, in the case of the synthesis of poly(GMA-co-EDMA) monoliths by photoinitiated free-radical polymerization, we demonstrated that the use of CyOH as the only porogen was absolutely sufficient to obtain a material with an average pore size of about 900-1000 nm. 28 In contrast, in the case of the preparation of poly(HPIEAA-co-GMA-co-EDMA), the use of CyOH as the only porogen led to the formation of a monolith with an average pore size of 30 nm (sample M1). Besides that, SEM data showed that the surface of this monolithic material had numerous defects [ Fig.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and investigation of a new macroporous monolithic material based on an N‐hydroxyphthalimide ester of acrylic acid‐co‐glycidyl methacrylate‐co‐ethylene dimethacrylate terpolymer

Slabospitskaya

Влах

Сапрыкина

et al. 2008

J of Applied Polymer Sci

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A macroporous monolithic material based on an N-hydroxyphthalimide ester of acrylic acid-co-glycidyl methacrylate-co-ethylene dimethacrylate terpolymer was synthesized by photoinitiated free-radical polymerization. Several porogenic solvents, such as cyclohexanol, dodecanol, and poly(ethylene glycol)s, were tested to obtain the monolithic material with an optimal pore size allowing unrestricted penetration of large molecule (proteins) into a three-dimensional porous space. The new monolithic material was covalently bound to an inert surface (glass) directly in the polymerization step, and it was suggested as a solid matrix for the development of new types of three-dimensional protein microarrays (biochips). A demonstration of the potential of the suggested microarray platform as well as optimization of microarray performance conditions was realized with a model mouse immunoglobulin G/goat anti-mouse immunoglobulin G affinity pair.

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“…It is known that structure formation of the monolithic polymer, par ticularly, AMA-EDMA copolymer, depends substantial ly on the nature and ratio of thermodynamically "bad" solvents (porogens) in the organic phase. 7, 8 The high affin ity of the porogens to alkyl methacrylates in the composition of monoliths OMA-EDMA 5 and LMA-EDMA 6 is like ly to transform the "bad" porogens into "good" solvents and thus decreases sharply the fraction of macropores in the monolith structure. Thus, at this stage of the work we conclude that the further elongation of the alkyl radical in the alkyl methacrylate molecule with retention of the de scribed procedure of synthesis has no prospects.…”

Section: Resultsmentioning

confidence: 99%

Poly(alkyl methacrylate) monolithic columns for HPLC

et al. 2008

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Several monolithic macroporous polymer sorbents (pore size 1-2 μm) based on alkyl meth acrylates and ethylene glycol dimethacrylate as a cross linking agent were prepared by free radical copolymerization in columns 3×150 mm. The influence of compositions of the reaction mixture and porogens and the nature of the alkyl radical in a mixture of monomers on the hydrodynamic and chromatographic characteristics of the monoliths was studied. The mono liths based on n butyl methacrylate have rigid macroporous morphology and excellent hydrody namic characteristics (flow rate up to 5 mL min -1 ). The efficiency of separation of a mixture of benzene and its derivatives in the version of reversed phase HPLC was shown to increase with an increase in the fraction of a lauryl methacrylate additive (LMA) in the reaction mixture. The maximum separation efficiency (number of theoretical plates (tp)) was 35 000 tp m -1 for the monolith based on n butyl methacrylate with 7% LMA in the reaction mixture.

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Synthesis and Pore Structure of Monolithic Polymeric Sorbents

Cited by 10 publications

References 19 publications

Preparation of methacrylate monoliths

Preparation of methacrylate monoliths

Synthesis and investigation of a new macroporous monolithic material based on an N‐hydroxyphthalimide ester of acrylic acid‐co‐glycidyl methacrylate‐co‐ethylene dimethacrylate terpolymer

Poly(alkyl methacrylate) monolithic columns for HPLC

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