Synthesis and potential cytotoxic activity of new phenanthrylphenol-pyrrolobenzodiazepines

Ligand Steric Effects of α-Diimine Nickel(II) and Palladium(II) Complexes in the Suzuki–Miyaura Cross-Coupling Reaction

“…1 H NMR (500 MHz, CDCl 3 , 300 K): δ (ppm): 8.78 (d, J = 8.25 Hz, 1H), 8.73 (d, J = 8.2 Hz, 1H), 7.95 (d, J = 8.25 Hz, 1H), 7.89 (d, J = 7.9 Hz, 1H), 7.69–7.65 (m, 3H), 7.62 (t, J = 6.8 Hz, 1H), 7.55 (d, J = 7.1 Hz, 1H), 7.43 (d, J = 8.5 Hz, 2H), 6.99 (d, J = 8.55 Hz, 2H), 4.90 (s, 1H). 1 H NMR data are consistent with the reported literature …”

“…93 The highest reported yield of 3A6 is achieved through SMC of 4-methoxyphenylboronic acid and 9bromophenanthrene followed by the demethylation process. 94 Also, the yield is much lower (80%) than our catalytic systems comprising Ni B (96%) and Pd B (94%). Compound 3A7 exhibited better yields with Ni B (95%) and Pd B (93%) than the reported yield (54%) with commercially available Pd-(PPh 3 ) 4 , including lithium N-phenylsydnone-4-carboxylate as an additive.…”

“…Also, 3A4 provided higher yields through Ni B (95%) and Pd B (90%) than the catalytic system possessing 5 mol % of commercially available bis­(triphenylphosphine)­palladium­(II) dichloride . The highest reported yield of 3A6 is achieved through SMC of 4-methoxyphenylboronic acid and 9-bromophenanthrene followed by the demethylation process . Also, the yield is much lower (80%) than our catalytic systems comprising Ni B (96%) and Pd B (94%).…”

Carbazole–pyrrolo[2,1-c][1,4]benzodiazepine conjugates: design, synthesis, and biological evaluation

“…[18][19][20][21][22][23][24][25][26][27][28][29][30][31] As a part of our ongoing exploration aimed towards the discovery of new PBD conjugates, we have investigated several potent PBD conjugates. [32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] In continuation of these efforts, in this article we have synthesized and evaluated a series of PBD-carbazole conjugates to unravel their anticancer potential. The significant DNA binding ability and the proficient cytotoxicity of these conjugates prompted us to further evaluate detailed biological effects.…”

Pyrrolobenzodiazepines as Sequence Selective DNA Binding Agents

“…The DNA binding ability of these novel PBD conjugates is usually investigated by thermal denaturation studies using calf thymus (CT) duplex DNA at pH 7.0 employing the protocols reported in the previous studies. [67,74] All the PBD conjugates showed better melting temperature of CT-DNA compared to the naturally occurring DC-81. The DNA melting temperature studies indicate that these PBD conjugates exhibit significant DNA binding affinity.…”