Synthesis and Preliminary Antimicrobial Activity of New Schiff Bases of Pyrido [1,2-A] Pyrimidine Derivatives with Certain Amino Acids

Abstract

The following pathogenic bacteria and fungi are used to evaluate the antimicrobial activity of the newly synthesized compounds. Pseudomonas aurginosa (P. auroginosa, ATCC 27853), Staphylococcus aurueus (S. aurueus, ATCC 25923), Bacillus subtilus (B. subtilus, ATCC 6633), Candida albicans (C. albicans, isolated from a local hospital and was inoculated on a chocolate agar plate and grown at 37°C for 48 h) and Escherichia coli (E. coli, ATCC 29522) cultured on Mueller Hinton agar.

A New Pyrimidine Schiff Base with Selective Activities against Enterococcus faecalis and Gastric Adenocarcinoma

“…Antibacterial and antifungal effects of imines of pyridi[1,2-a]pyrimidine ( Figure 1 d) and various amino acids were reported. Researchers found that aromatic amino acid compounds are more potent than aliphatic amino acid compounds [ 22 ]. Strong antifungal activity was also exhibited by Shiff bases ( Figure 1 e) and phenylhydrasones ( Figure 1 f) of pyrimidinetriones.…”

Design, Synthesis, In Silico Study and Anti-Inflammatory Evaluation of New Ketoprofen Thiourea Derivatives

“…The initial stage of chemical production entails the nucleophilic assault of NH2 from thiosemicarbazide in the carbon atom in the ketoprofen carbonyl group, leading to creation of a schiff base bond (C=N) intermediate (A) (21) .…”

Pyrimidine Schiff Bases: Synthesis, Structural Characterization and Recent Studies on Biological Activities

“…Pyrimidine exhibits wide occurrence in nature as a constituent of nucleic acids, thymine, and many other natural and synthetic compounds including drugs [28][29][30], and over time it has become known as an effective pharmacophore. In the most common cases, the amino group attached to the pyrimidine ring is exploited to form the imine group in reaction with aldehydes [31][32][33][34][35], and in some cases pyrimidine-5-carbaldehyde is also used [36][37][38][39].…”