Synthesis and preliminary therapeutic evaluation of copper nanoparticles against diabetes mellitus and -induced micro- (renal) and macro-vascular (vascular endothelial and cardiovascular) abnormalities in rats

Sharma, Arun Kumar; Kumar, Ashish; Taneja, Gaurav; Nagaich, Upendra; Deep, Aakash; Rajput, Satyendra K.

doi:10.1039/c6ra03890e

Cited by 39 publications

(21 citation statements)

References 57 publications

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“…For example, CuNPs can be synthetized with a reduction of copper from a copper nitrate salt in the presence of iron, and to prevent the formation of larger sized CuNPs, the sample was continuously ultra-sonicated. The obtained nanoparticles sizes were recorded between 90 and 150 nm [38].…”

Section: Cementation Methodsmentioning

confidence: 99%

Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

et al. 2020

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Metal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to their reduced size and selectivity for bacteria, metal-based nanoparticles have also proved to be effective against pathogens listed as a priority. Metal-based nanoparticles are known to have non-specific bacterial toxicity mechanisms (they do not bind to a specific receptor in the bacterial cell) which not only makes the development of resistance by bacteria difficult, but also broadens the spectrum of antibacterial activity. As a result, a large majority of metal-based nanoparticles efficacy studies performed so far have shown promising results in both Gram-positive and Gram-negative bacteria. The aim of this review has been a comprehensive discussion of the state of the art on the use of the most relevant types of metal nanoparticles employed as antimicrobial agents. A special emphasis to silver nanoparticles is given, while others (e.g., gold, zinc oxide, copper, and copper oxide nanoparticles) commonly used in antibiotherapy are also reviewed. The novelty of this review relies on the comparative discussion of the different types of metal nanoparticles, their production methods, physicochemical characterization, and pharmacokinetics together with the toxicological risk encountered with the use of different types of nanoparticles as antimicrobial agents. Their added-value in the development of alternative, more effective antibiotics against multi-resistant Gram-negative bacteria has been highlighted.

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Section: Cementation Methodsmentioning

confidence: 99%

Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

et al. 2020

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“…Modified response to ACh [6] and increased contraction to prostaglandin F 2 -alpha were observed [7] with no attenuation of endothelin-1-induced contraction [7]. Surprisingly, several studies have reported a beneficial anti-diabetic and cardioprotective role of CuNPs with a decreased production of inflammatory mediators [8,9,10,11,12].…”

Section: Introductionmentioning

confidence: 97%

Dietary supplementation with copper nanoparticles influences the markers of oxidative stress and modulates vasodilation of thoracic arteries in young Wistar rats

et al. 2020

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We aimed to study the physiological effects of diet supplemented with copper (Cu) nanoparticles (NPs). During the eight weeks of the experiment, young Wistar rats (at seven weeks of age, n = 9) were supplemented with 6.5 mg of Cu either as NPs or carbonate salt (Cu 6.5). A diet that was not supplemented with Cu served as a negative control (Cu 0). The impact of nano Cu supplementation on lipid (reflected as thiobarbituric acid reactive substances-TBARS) and protein peroxidation (thiol and carbonyl groups) in blood plasma as well as the influence on the vasodilatory mechanism(s) of isolated rat thoracic arteries were studied. Supplementation with Cu enhanced lipid peroxidation (TBARS) in NP 6.5 (x2.4) and in Cu 6.5 (x1.9) compared to the negative control. Significant increase in TBARS was also observed in NP 6.5 (x1.3) compared to the Cu 6.5 group. The level of thiol groups increased in NP 6.5 (x1.6) compared to Cu 6.5. Meanwhile, significant (x0.6) decrease was observed in the Cu 6.5 group compared to the negative control. Another marker of protein oxidation, carbonyl groups increased in NP 6.5 (x1.4) and Cu 6.5 (x2.3) compared to the negative control. However significant difference (x0.6) was observed between NP 6.5 and Cu 6.5. Arteries from Cu supplemented rats exhibited an enhanced vasodilation to gasotransmitters: nitric oxide (NO) and carbon monoxide (CO). An enhanced vasodilation to NO was reflected in the increased response to acetylcholine (ACh) and calcium ionophore A23187. The observed responses to ACh and CO releasing molecule (CORM-2) were more pronounced in NP 6.5. The activator of cGMP-dependent protein kinases (8-bromo-cGMP) induced similar vasodilation of thoracic arteries in NP 6.5 and Cu 0 groups, while an increased response was observed in the Cu 6.5 group. Preincubation with the inducible nitric oxide (iNOS) synthase inhibitor-1400W, decreased the ACh-induced vasodilation in NP 6.5 , exclusively. Meanwhile the eicosanoid metabolite of arachidonic acid (20-HETE) synthesis inhibitor-HET0016, enhanced vasodilation of arteries from Cu 0 group. In conclusion, this study demonstrates that supplementation with nano Cu influences oxidative stress, which further has modified the vascular response.

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“…ROS mediated disruption may increase the release of CKMB, LDH and cTnI enzyme into the serum. 16,31,33 Furthermore, increased ROS concomitantly decreases the work functionality of renal system. 16,33 Altered glomerular ltration rate or deterioration in renal function was reected by the increase in BUN and creatinine, as well as the occurrence of microproteinuria.…”

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confidence: 99%

“…16,31,33 Furthermore, increased ROS concomitantly decreases the work functionality of renal system. 16,33 Altered glomerular ltration rate or deterioration in renal function was reected by the increase in BUN and creatinine, as well as the occurrence of microproteinuria. 16,33 The alcohol/disulram-induced deleterious effects on the renal system were indicated by the increased level of serum BUN, creatinine and the occurrence of microproteinuria.…”

mentioning

confidence: 99%

“…16,33 Altered glomerular ltration rate or deterioration in renal function was reected by the increase in BUN and creatinine, as well as the occurrence of microproteinuria. 16,33 The alcohol/disulram-induced deleterious effects on the renal system were indicated by the increased level of serum BUN, creatinine and the occurrence of microproteinuria. Cardio-renal protection was evident from the improved structural and functional parameters of the heart and kidney tissues.…”

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confidence: 99%

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Preparation and therapeutic evolution of Ficus benjamina solid lipid nanoparticles against alcohol abuse/antabuse induced hepatotoxicity and cardio-renal injury

Sharma

Kumar

et al. 2017

RSC Adv.

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Chronic alcoholism destroys the propensity for hepatic detoxification of toxic substances, which further promotes the rapid and intense accumulation of aldehydes in the liver. Subsequently, chronic alcoholism exerts fatal liver and cardio-renal injury caused by fat deposition, dyslipidemia, inflammation and oxidative stress. The consequence becomes more perilous in disulfiram (potent aldehydes dehydrogenase inhibitor)-allied alcoholism, which further increases hepatic aldehyde accumulation by inhibiting aldehyde dehydrogenase. Ficus benjamina (F. benjamina) is rich in phenolic and total flavonoid content and demonstrates effective antioxidant, anti-inflammatory, antinociceptive, antipyretic, hypotensive, anti-dysentery and antimicrobial properties. Numerous formulations of Ficus benjamina solid lipid nanoparticles (FBSLNP) were prepared and characterized using several physicochemical and drug stability parameters including entrapment efficiency, particle size, zeta potential, and TEM and in vitro drug release studies. In vivo evaluation of FBSLNP was carried out against hepatic and cardio-renal injury induced by concurrent administration of alcohol and disulfiram. Imperative recoveries in studies involving biological parameters including SGPT/SGOT, alkaline phosphatase level, lipid profile, serum protein and oxidative stress, and histological photomicrography revealed the hepatoprotective action of FBSLNP. Reduced levels of accumulated aldehydes in liver tissue were observed via gas chromatography, which confirmed the detoxifying nature of FBSLNP. Moreover, the restoration of aberrant cardio-renal biomarkers (CKMB, LDH, cTnI and serum creatinine, blood urea nitrogen, and microproteinuria) and histological consequences significantly reveal the cardio-renal protective potential of FBSLNP against alcohol abuse/antabuse-associated injury. Considering the results, it may conclude that the significant protection by FBSLNP is based on its anti-oxidant, anti-inflammatory and detoxification potential with regard to accumulated hepatic aldehydes.

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Synthesis and preliminary therapeutic evaluation of copper nanoparticles against diabetes mellitus and -induced micro- (renal) and macro-vascular (vascular endothelial and cardiovascular) abnormalities in rats

Abstract: Current study synthesized and investigated the effect of low-dose copper nanoparticles (CuNPs) against diabetes mellitus and -induced experimental micro- (nephropathy) and macro-vascular (cardio and endothelium) complications.

Cited by 39 publications

References 57 publications

Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

Dietary supplementation with copper nanoparticles influences the markers of oxidative stress and modulates vasodilation of thoracic arteries in young Wistar rats

Preparation and therapeutic evolution of Ficus benjamina solid lipid nanoparticles against alcohol abuse/antabuse induced hepatotoxicity and cardio-renal injury

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