Synthesis and properties of (6-methyl-2-oxo-4-thioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)acetic acid methyl ester

Abstract

On interacting of the methyl ester of (6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)acetic acid with the Lawesson's reagent the corresponding 4-thioxo derivative is synthesized. Its alkylation with methyl bromoacetate has been studied as has its interaction with N-nucleophiles, amines, and hydrazines.

Regioselective synthesis of 7,8-dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives: A new drug-like heterocyclic scaffold

“…The proposed intramolecular N1–C5 heterocondensation as a key step to form the desired imidazo[5,1- c ][1,2,4]triazine-3,6-diones 23 – 25 was accomplished by reaction of the thioxoimidazolidines 20 – 22 with hydrazine hydrate [23–26]. Different reaction conditions were applied, e.g., variation of the solvent or the amount of hydrazine monohydrate that was used.…”