On interacting of the methyl ester of (6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)acetic acid with the Lawesson's reagent the corresponding 4-thioxo derivative is synthesized. Its alkylation with methyl bromoacetate has been studied as has its interaction with N-nucleophiles, amines, and hydrazines.

Ester. -A facile procedure for the selective monothionation of 2,4-dioxopyrimidinylacetate (I) to furnish the title 4-thioxo derivative (II) is developed. Its reactions with some C-and N-nucleophiles are described. -(JAKUBKIENE*, V.; PAULAUSKAITE, R.; VAINILAVICIUS, P.; Chem. Heterocycl. Compd. (N. Y.) 43 (2007) 4, 485-489; Univ. Vilnius, Vilnius 01513, Lithuania; Eng.) -A. Forchert 52-146