Synthesis and properties of a novel hyperbranched polyphosphoramidate using an A₂ + CB₂ approach

Abstract

The synthesis of hyperbranched polyphosphoramidate (HPPAE) has been successfully achieved via a facial A2 + CB2 approach. First, an AB2 type intermediate is generated by the reaction between the phosphorus chloride group of ethyldichlorophosphate and the secondary amine group of diethanolamine. Second, the above intermediate can further self‐condense to produce the hyperbranched polymer. The molecular weight and the structural characterization of HPPAE were checked by gel permeation chromatography and Fourier transform infrared and NMR (13C and 31P) spectroscopy. The degradation study of HPPAE indicated that phosphate and phosphoramide bonds between the branch points are responsible for its complete hydrolysis in an aqueous phosphate buffer (pH 7.4) after 6 days. In addition, HPPAE presents a strong fluorescence peak at 450 nm, exhibiting the potential to track drug transport and distribution in real time. © 2012 Society of Chemical Industry

A Theoretical Investigation of the Polyaddition of an AB2+A2+B4 Monomer Mixture

“…To describe the polyaddition of A2+CB2 Scheme 1. Synthesis of HBP by polyaddition of the monomer types A 2 +B 3 [23][24][25], A 2 +B 4 [26][27][28], A 2 +CB 2 [29][30][31], and A 2 +B B 2 [32][33][34].…”

“…To reduce the p g value, co-polyaddition of asymmetric monomers (A 2 +CB 2 , A 2 +B B 2 , AA +B 3 , A 2 +C 2 +B 3 ) was introduced [29][30][31][32][33][34][35][36][37][38][39] (Scheme 1). These approaches made it possible to shift the gel point, since more AB 2 monomers were formed, and therefore, it was possible to obtain polymers with an increased MW.…”

Crystallization behaviour and lamellar thickness distribution of metallocene‐catalyzed polymer: Effect of 1‐alkene comonomer and branch length

“…Therefore, the knowledge of polymer crystallization kinetics and resulting degree of crystallinity are helpful tools for its processing and desired characteristics. [11,12] Several studies have been done for better understanding of the concepts linked with isothermal and non-isothermal crystallization behaviour of PE. [13,14] The non-isothermal crystallization kinetics has more practical significance over the isothermal kinetics study due to its industrial applications.…”