Synthesis and radioprotective properties of amides of phosphoric and thiophosphoric acids

Synthesis and radioprotective activity of the products of reactions between cyclic anhydrides of β-(oxysulfinyl)carboxylic acids and amines

“…However, the radioprotective activity of the latter salt was also markedly higher: 47 -53% [2] against 0 -13% for the binary salts VI and VII. In contrast to what was reported in [4], cyclohexylamides IV, VIII, and IX obtained by the acylation of CHA are inactive or exhibit a weak radioprotective activity. Immortium salt XIII produced a small protective effect (not exceeding 24%) only when introduced lh before irradiation.…”

“…It was established that most of the newly synthesized amides are of low toxicity. Acylation with anhydrides III, XI, and XIV decreases the toxicity ofCHA (LDs0 = 129 mg/kg [4]) to 1/6 -1/7 of the initial level. For example, the LDs0 of cyclohexylamides IV, VIII, and IX fall within 750 -950 mg/kg.…”

“…In continuation of that work, we have studied the radioprotective activity of the products of reactions between cyclic anhydrides of 13-(oxysulfinyl)carboxylic acids and other amines, including aniline, cyelohexylamine (CHA), 1-adamantylamine (1-AdNH2), and bis(dimethylamino)methane. Our interest in the eycloaliphatic amines is stimulated by the fact that radioproteetive properties were observed in derivatives ofadamantane [3] and CHA [4]. As is known, the acylation of amines sometimes leads to compounds possessing pronotmced radioprotective activity [4].…”

“…Our interest in the eycloaliphatic amines is stimulated by the fact that radioproteetive properties were observed in derivatives ofadamantane [3] and CHA [4]. As is known, the acylation of amines sometimes leads to compounds possessing pronotmced radioprotective activity [4].…”