“…Scheme 4). Ethyl acetoacetate 15a [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] ethyl cyanoacetate 15b, [51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66] cyanoanilides 15c, [67][68][69] benzoylacetonitrile 15d 70 and cyanothioacetamide 15f 71,72 couple readily with aromatic diazonium salt in presence of sodium acetate to yield corresponding arylhydrazones whose exact geometry has only been recently established 16 (cf. Scheme 5).…”
Synthetic approaches and chemical reactivity of title compounds since 1894 to date are reported. Emphasis is placed on pinpointing old literature reports that need reinspection in light of modern techniques and recent advances in utilizing the title compounds as precursors to polyfunctional heteroaromatics.
“…Scheme 4). Ethyl acetoacetate 15a [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] ethyl cyanoacetate 15b, [51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66] cyanoanilides 15c, [67][68][69] benzoylacetonitrile 15d 70 and cyanothioacetamide 15f 71,72 couple readily with aromatic diazonium salt in presence of sodium acetate to yield corresponding arylhydrazones whose exact geometry has only been recently established 16 (cf. Scheme 5).…”
Synthetic approaches and chemical reactivity of title compounds since 1894 to date are reported. Emphasis is placed on pinpointing old literature reports that need reinspection in light of modern techniques and recent advances in utilizing the title compounds as precursors to polyfunctional heteroaromatics.
“…Elemental analyses were carried out at the Microanalytical Center of Cairo University. 2-Cyano-N-(2-pyridyl)acetamide (1), 27 hydrazonoyl chlorides 2a, 28 2b, 29 and 2c-e, 30 were prepared following literatured procedures.…”
“…Elemental analysis were carried out at the microanalytical laboratory, University of Cairo, Giza, Egypt. The hydrazonoyl chlorides 1a-e 23,26,27 and α-amino ester hydrochlorides 3a-e 3 were prepared following reported procedures.…”
1-Aryl-3-phenylaminocarbonyl-4,5-dihydro-1,4,5-triazin-6-ones were prepared from the reaction of C-phenylaminocarbonyl-N-arylnitrilimines with α-amino acid methyl esters. Some of these compounds were tested for antitumor activity.
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