Synthesis and release behavior of composites of camptothecin and layered double hydroxide

Dong, Lun; Li, Yan; Hou, Wanguo; Liu, Shaojie

doi:10.1016/j.jssc.2010.05.035

Cited by 89 publications

(83 citation statements)

References 21 publications

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“…The common models used include pseudo-first order, pseudo-second order, and parabolic diffusion models. Pseudo-first order kinetic equation is written as follows: 57 In q q…”

Section: Determination Of Average Size and Size Distribution Propertiesmentioning

confidence: 99%

Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system

Barahuie

Dorniani

Saifullah

et al. 2017

IJN

105

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“…The common models used include pseudo-first order, pseudo-second order, and parabolic diffusion models. Pseudo-first order kinetic equation is written as follows: 57 In q q…”

Section: Determination Of Average Size and Size Distribution Propertiesmentioning

confidence: 99%

Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system

Barahuie

Dorniani

Saifullah

et al. 2017

IJN

105

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“…The pseudo-first order kinetics mathematical model equation ln(q e − q t ) = lnq e − k 1 t (q e and q t are the equilibrium release amount and the release amount at time t, respectively), 17 the pseudo-second order equation t/q t = 1/k 2 q e 2 + t/q e 18 and the parabolic diffusion equation (1 − M t /M o )/t = kt −0.5 + b (M o and M t are the drug content that remained in LDH at the release times of 0 and t, respectively) 19 were used. alone, cell viability was reduced by more than 40% when the concentration of the hybrid exceeded 100 µg/mL.…”

Section: Surface Propertiesmentioning

confidence: 99%

Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent

Kura¹,

Ali²,

Hussein³

et al. 2013

IJN

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Abstract:A new layered organic-inorganic nanocomposite material with an anti-parkinsonian active compound, L-3-(3,4-dihydroxyphenyl) alanine (levodopa), intercalated into the inorganic interlayers of a Zn/Al-layered double hydroxide (LDH) was synthesized using a direct coprecipitation method. The resulting nanocomposite was composed of the organic moiety, levodopa, sandwiched between Zn/Al-LDH inorganic interlayers. The basal spacing of the resulting nanocomposite was 10.9 Å. The estimated loading of levodopa in the nanocomposite was approximately 16% (w/w). A Fourier transform infrared study showed that the absorption bands of the nanocomposite were characteristic of both levodopa and Zn/Al-LDH, which further confirmed intercalation, and that the intercalated organic moiety in the nanocomposite was more thermally stable than free levodopa. The resulting nanocomposite showed sustained-release properties, so can be used in a controlled-release formulation. Cytotoxicity analysis using an MTT assay also showed increased cell viability of 3T3 cells exposed to the newly synthesized nanocomposite compared with those exposed to pure levodopa after 72 hours of exposure.

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“…Release profiles for cetirizine from CETN ( Figure 7I) show results similar to those of other drugs, such as 5-flurouracil, camptothecin, naproxen, l-Dopa, and 5-florocytosine, found in the literature. 22,24,[35][36][37][38] Release kinetics of cetirizine from CETN In order to better understand the mechanism of the release of cetirizine from CETN, the results of the kinetic studies were analyzed using pseudo-first order (Equation 1), 39 pseudo-second order (Equation 2), 40 ln (q e −q t ) = ln q e − k 1 t…”

Section: Release Behavior Of Cetirizinementioning

confidence: 99%

Controlled-release formulation of antihistamine based on cetirizine zinc-layered hydroxide nanocomposites and its effect on histamine release from basophilic leukemia (RBL-2H3) cells

Hasan¹,

Ali²,

Al‐Qubaisi³

et al. 2012

IJN

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Abstract:A controlled-release formulation of an antihistamine, cetirizine, was synthesized using zinc-layered hydroxide as the host and cetirizine as the guest. The resulting well-ordered nanolayered structure, a cetirizine nanocomposite "CETN," had a basal spacing of 33.9 Å, averaged from six harmonics observed from X-ray diffraction. The guest, cetirizine, was arranged in a horizontal bilayer between the zinc-layered hydroxide (ZLH) inorganic interlayers. Fourier transform infrared spectroscopy studies indicated that the intercalation takes place without major change in the structure of the guest and that the thermal stability of the guest in the nanocomposites is markedly enhanced. The loading of the guest in the nanocomposites was estimated to be about 49.4% (w/w). The release study showed that about 96% of the guest could be released in 80 hours by phosphate buffer solution at pH 7.4 compared with about 97% in 73 hours at pH 4.8. It was found that release was governed by pseudo-second order kinetics. Release of histamine from rat basophilic leukemia cells was found to be more sensitive to the intercalated cetirizine in the CETN compared with its free counterpart, with inhibition of 56% and 29%, respectively, at 62.5 ng/mL. The cytotoxicity assay toward Chang liver cells line show the IC 50 for CETN and ZLH are 617 and 670 μg/mL, respectively.

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Synthesis and release behavior of composites of camptothecin and layered double hydroxide

Cited by 89 publications

References 21 publications

Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system

Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system

Development of a controlled-release anti-parkinsonian nanodelivery system using levodopa as the active agent

Controlled-release formulation of antihistamine based on cetirizine zinc-layered hydroxide nanocomposites and its effect on histamine release from basophilic leukemia (RBL-2H3) cells

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