Synthesis and rheological characterization of a novel shear thinning levan gellan hydrogel

Nair, Revathy; Choudhury, Anirban Roy

doi:10.1016/j.ijbiomac.2020.05.119

Cited by 54 publications

(17 citation statements)

References 32 publications

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“…Shear-thinning hydrogel solutions can improve injectability of cell-loaded hydrogel solutions 40 and reduce damage to cells when the hydrogel solution passes through a pinhole or pipette tip. 41 However, more damage could be induced by fluid shear stress due to the addition of nHA.…”

Section: Resultsmentioning

confidence: 99%

Preparation and characterization of biomimetic gradient multi-layer cell-laden scaffolds for osteochondral integrated repair

Fan

Zhou

2022

J. Mater. Chem. B

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Section: Resultsmentioning

confidence: 99%

Preparation and characterization of biomimetic gradient multi-layer cell-laden scaffolds for osteochondral integrated repair

Fan

Zhou

2022

J. Mater. Chem. B

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“…In the viscosity measurement, the viscosities of all PDA@CD hydrogels were decreased with the increased shear rate, showing that these materials exhibited shear-thinning property (Figure d). The power law index is commonly used to describe the relationship between shear rate and shear stress with the equation of τ = κγ n (τ, κ, γ, and n represent shear stress (Pa), consistency coefficient (Pa·s), shear rate (s –1 ), and power law index, respectively) . When the power law value is less than 1, the fluid presents the manner of shear-thinning.…”

Section: Resultsmentioning

confidence: 99%

“…The power law index is commonly used to describe the relationship between shear rate and shear stress with the equation of τ = κγ n (τ, κ, γ, and n represent shear stress (Pa), consistency coefficient (Pa•s), shear rate (s −1 ), and power law index, respectively). 78 When the power law value is less than 1, the fluid presents the manner of shear-thinning. The power law indices of PDA10@ CD, PDA30@CD, and PDA50@CD hydrogels were calculated to be 0.818, 0.200, and 0.534, respectively (Figure 2e).…”

Section: Characterization Of Materialsmentioning

confidence: 99%

Synthesis and Processing of Dynamic Covalently Crosslinked Polydextran/Carbon Dot Nanocomposite Hydrogels with Tailorable Microstructures and Properties

Yeh

2022

ACS Biomater. Sci. Eng.

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Using functionalized nanoparticles to crosslink hydrophilic polymers is a growing theme of directly constructing nanocomposite (NC) hydrogels. Employing dynamic covalent chemistry at the nanoparticle–polymer interface is particularly attractive due to the spontaneous formation and reversible manner of dynamic covalent bonds. However, the structure and property modulation of the dynamic covalently crosslinked NC hydrogels has not been thoroughly discussed. Here, we fabricated NC hydrogels by using amine-functionalized carbon dots (CDs) to crosslink polydextran aldehyde (PDA) polymers through imine bond formation. The role of PDA with different oxidation degrees (i.e., PDA10, PDA30, and PDA50) in affecting the microstructures and properties of PDA@CD hydrogels was systematically investigated, showing that the PDA50@CD hydrogel presented the densest structure and the highest mechanical strength among the three PDA@CD hydrogels. The pH-responsiveness, 3D printing, electrospinning, and biocompatibility of PDA@CD hydrogels were also demonstrated, showing the great promise of using PDA@CD hydrogels for applications in biomedicine and biofabrication.

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“…The values of the shear stress at the limit of the LVE region and at the crossover point G ′ = G ″ are referred to as yield stress (σ Y ) and flow stress (σ F ), respectively. The ratio of σ F :σ Y , defined as the flow transition index (FTI), characterized the breaking behavior of the inner structure, which illustrates the brittle behavior of the soft material as FTI approaches 1. , Interestingly, FTI was found to increase with the doping of supramolecular 1 NF fibers into the polysaccharide network, while the FTI value for P0 remained close to 1, reflecting its brittle nature (Figure C). The steady increase in the FTI values illustrated the elastic stiffness of the gels and possible dissipation of energy as imparted by the incorporation of sacrificial supramolecular 1 NF fibers.…”

Section: Resultsmentioning

confidence: 99%

Mechanical Integrity in a Dynamic Interpenetrating Hydrogel Network of Supramolecular Peptide–Polysaccharide Supports Enhanced Chondrogenesis

Thomas¹,

Gupta²,

Joseph³

et al. 2021

ACS Biomater. Sci. Eng.

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Tissue engineering demands intelligently designed scaffolds that encompass the properties of the target tissues in terms of mechanical and bioactive properties. An ideal scaffold for engineering a cartilage tissue should provide the chondrocytes with a favorable 3D microarchitecture apart from possessing optimal mechanical characteristics such as compressibility, energy dissipation, strain stiffening, etc. Herein, we used a unique design approach to develop a hydrogel having a dynamic interpenetrating network to serve as a framework to support chondrocyte growth and differentiation. An amyloid-inspired peptide amphiphile (1) was self-assembled to furnish kinetically controlled nanofibers and incorporated in a dynamic covalently cross-linked polysaccharide network of carboxymethyl cellulose dialdehyde (CMC-D) and carboxymethyl chitosan (CMCh) using Schiff base chemistry. The dynamic noncovalent interaction played a pivotal role in providing the desired modulation in the structure and mechanical properties of the double-network hydrogels that are imperative for cartilage scaffold design. The adaptable nature supported shear-induced extrusion of the hydrogel and facilitated various cellular functions while maintaining its integrity. The potential of the as-developed hydrogels to support in vitro chondrogenesis was explored using human chondrocytes. Evidence of improved cell growth and cartilage-specific ECM production confirmed the potential of the hydrogel to support cartilage tissue engineering while reaffirming the significance of mimicking the biophysical microenvironment to induce optimal tissue regeneration.

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Synthesis and rheological characterization of a novel shear thinning levan gellan hydrogel

Cited by 54 publications

References 32 publications

Preparation and characterization of biomimetic gradient multi-layer cell-laden scaffolds for osteochondral integrated repair

Preparation and characterization of biomimetic gradient multi-layer cell-laden scaffolds for osteochondral integrated repair

Synthesis and Processing of Dynamic Covalently Crosslinked Polydextran/Carbon Dot Nanocomposite Hydrogels with Tailorable Microstructures and Properties

Mechanical Integrity in a Dynamic Interpenetrating Hydrogel Network of Supramolecular Peptide–Polysaccharide Supports Enhanced Chondrogenesis

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