Synthesis and SAR/3D-QSAR studies on the COX-2 inhibitory activity of 1,5-diarylpyrazoles to validate the modified pharmacophore

Synthesis and antinociceptive-antimicrobial activities of some new amide derivatives of 3,5-di/-and 1,3,5-trimethylpyrazoles

“…Also deracoxib (Deramaxxe) is already used for the treatment of pain and inflammation in dogs [2,3]. Furthermore, there are various reports which have demonstrated the analgesic-antiinflammatory effects of pyrazole derivatives [4][5][6][7][8][9][10][11][12][13].…”

New 4-fluoroalkyl substituted N-phenylpyrazoles: Synthesis promoted by DAST and multinuclear NMR analysis

“…The NMR literature data is limited in relation to CH 2 F and CHF 2 groups attached to pyrazole rings even for the most common substituted 3 and 5 positions [31][32][33][34]. In general, mono and difluoromethyl groups do not show great variation of chemical shifts in aromatic pyrazole ring independent of their positions in the heterocycle [35,36].…”

2-{5-[2-(4-Nitrophenoxy)phenyl]-1-phenyl-1H-pyrazol-3-yl}phenol

“…For pyrazole-containing derivatives, see: Habeeb et al (2001); Hashimoto et al (2002); Ranatunge et al (2004); Elzein et al (2006); Singh et al (2005). For the properties and applications of aromatic polymers with diazole rings in the main chain, see: Bruma et al (2003); Sava et al (2003Sava et al ( , 2006; Schulz et al (1997).…”

“…The pyrazole unit is one of the core structures in a number of natural products and has been attracted attention in the field of biology (Habeeb et al, 2001, Hashimoto et al 2002. Extensive studies have been devoted to arylpyrazole derivatives such as celecoxib,a well-known cyclooxygenase-2 inhibitor (Ranatunge et al, 2004;Singh et al 2005). Recently, pyrazole derivatives have been reported as high affinity and selective A2B adenosine receptor antagonist (Elzein et al, 2006).…”