Synthesis and Screening of Some Novel 2-[5-(Substituted phenyl)-[1,3,4]oxadiazol-2-yl]-benzoxazoles as Potential Antimicrobial Agents

Gadegoni, Hemalatha; Sarangapani, M.; Rangu, Shivaprasad

doi:10.5012/jkcs.2013.57.2.221

Cited by 12 publications

(6 citation statements)

References 30 publications

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“…Benzoxazoles are regarded as a promising class of bioactive heterocyclic compounds that exhibit a range of biological activities such as antifungal, antibacterial, antiviral, anti-HIV, antihelmintic, antiinflammatory, etc. [11][12][13][14][15][16][17][18][19][20][21] . In continuation of our research work [22][23][24][25] , we report here the synthesis and biological activities of organophosphate phenoxy derivatives derived from 2-mercapto benzoxazole.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Activity of Organophosphates Phenoxy Derivatives Derived from 2-Mercapto Benzoxazole

Jain

Choudhary

Nagar

et al. 2014

Phosphorus, Sulfur, and Silicon and the Related Elements

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A series of biologically active phenoxy derivatives of 2-substituted benzoxazole organophosphates have been synthesized by the reaction of S-(benzoxazolyl-2)phosphorodichloridothioate/phosphorodichloridodithioate with phenol/4-chlorophenol/4-nitrophenol in 1:1 and 1:2 molar ratio. These compounds have been characterized by elemental analysis, IR, 1 H NMR, and 31 P NMR spectral studies. The antibacterial activity of these 2-substituted benzoxazolephenoxy derivatives has been evaluated against pathogenic bacteria Staphylococcus aureus (+ve) and Escherichia coli (-ve). The antifungal activity of these 2-substituted benzoxazolephenoxy derivatives has been evaluated against pathogenic fungi Aspergillusniger and Fusariumoxysporium. All the compounds were found to have moderate antibacterial and antifungal activity.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Activity of Organophosphates Phenoxy Derivatives Derived from 2-Mercapto Benzoxazole

Jain

Choudhary

Nagar

et al. 2014

Phosphorus, Sulfur, and Silicon and the Related Elements

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“…The structure of the nanocatalyst confirmed by XRD, SEM, TEM, N 2 adsorption-desorption, FTIR and EDS (Energy Dispersive Spectroscopy) techniques. In this method, initially, coumarin-3-carboxylates are synthesised from an ultrasonic reaction between a 2-aminophenol derivative (25) and diethyl malonate (26) by using MgFe 2 O 4 nanocatalyst. The synthesised nanocatalyst was applied in the preparation of 3benzoxazol-2-yl-chromen-2-one derivatives (29) through the reaction of different coumarin-3-carboxylates ( 27) and 2-aminophenol derivatives under ethanol at reflux (28) (Scheme 8).…”

Section: Mode Of Activationmentioning

confidence: 99%

“…The synthesis of the compound ( 8 ) began with commercially available benzoxazole‐2‐carboxylic acid ( 5 ). The benzoxazole‐2‐carbonyl chloride ( 6 ), the key intermediate, has been prepared in 69% yield by stirring a mixture of benzoxazole‐2‐carboxylic acid ( 5 ) and thionyl chloride in the presence of ethanol solvent at room temperature for 3 h, as in Scheme 2 [25] …”

Section: Introductionmentioning

confidence: 99%

Nanocatalyzed Synthesis of Benzoxazoles

Patel,

Patil,

Chavan

et al. 2023

ChemistrySelect

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Naturally, occurring as well as synthetic nitrogen and oxygen containing heterocyclic compounds like benzoxazoles and its derivatives have found to be playing a vital role in the Pharmaceutical, agriculture; polymer, material science and they also exhibits series of significant antimicrobial activities. In the last decade, an organic transformation has found abundant application of nanotechnology and nanoscience can aid design catalyst with excellent efficiency, selectivity and stability. Academics and industry have recently shown a lot of interest in the application of nanocatalysts, a field that is expanding significantly, to create sustainable and environmentally friendly processes for the synthesis of benzoxazole derivatives with multi‐component reactions (MCRs). Nanocatalyst reactions have advantages over conventional catalyst reactions because of the interaction of chemical reactants made possible by a high surface area ratio, simple purification, low catalyst loading, high atom economy, inexpensiveness, short reaction time, better yield, and recyclability of the nanocatalysts. In this review article, mainly focus is on the nanocatalysts fabrications, characterizations and their applications for the synthesis of benzoxazoles moiety during the last decennary (2011 to 2022).

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“…Benzamides and benzoxazole derivatives are known to possess a wide array of biological activities such as anti‐inflammatory, anti‐bacterial, antifungal, anti‐convulsant, and analgesic activity . The literature data showed that benzamides and benzoxazole moiety (G–I) (Figure ) can be a potent template for COX‐2 inhibitory activity, with GI safety margins .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, molecular docking, and pharmacological evaluation of N‐(2‐(3,5‐dimethoxyphenyl)benzoxazole‐5‐yl)benzamide derivatives as selective COX‐2 inhibitors and anti‐inflammatory agents

Kaur

Pathak

Sharma

et al. 2018

Archiv der Pharmazie

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A series of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives (3am) was synthesized and evaluated for their in vitro inhibitory activity against COX-1 and COX-2. The compounds with considerable in vitro activity (IC < 1 μM) were evaluated in vivo for their anti-inflammatory potential by the carrageenan-induced rat paw edema method. Out of 13 newly synthesized compounds, 3a, 3b, 3d, 3g, 3j, and 3k were found to be the most potent COX-2 inhibitors in the in vitro enzymatic assay, with IC values in the range of 0.06-0.71 μM. The in vivo anti-inflammatory activity of these six compounds (3a, 3b, 3d, 3g, 3j, and 3k) was assessed by the carrageenan-induced rat paw edema method. Compounds 3d (84.09%), 3g (79.54%), and 3a (70.45%) demonstrated significant anti-inflammatory activity compared to the standard drug ibuprofen (65.90%) and were also found to be safer than ibuprofen, by ulcerogenic studies. A docking study was done using the crystal structure of human COX-2, to understand the binding mechanism of these inhibitors to the active site of COX-2.

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Synthesis and Screening of Some Novel 2-[5-(Substituted phenyl)-[1,3,4]oxadiazol-2-yl]-benzoxazoles as Potential Antimicrobial Agents

Cited by 12 publications

References 30 publications

Synthesis and Biological Activity of Organophosphates Phenoxy Derivatives Derived from 2-Mercapto Benzoxazole

Synthesis and Biological Activity of Organophosphates Phenoxy Derivatives Derived from 2-Mercapto Benzoxazole

Nanocatalyzed Synthesis of Benzoxazoles

Synthesis, molecular docking, and pharmacological evaluation of N‐(2‐(3,5‐dimethoxyphenyl)benzoxazole‐5‐yl)benzamide derivatives as selective COX‐2 inhibitors and anti‐inflammatory agents

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