Synthesis and Self Assembly of Hydrogen‐Bonded Supramolecular Polymers

Farnik, Dominique; Kluger, Christian; Kunz, Michael J.; Machl, Doris; Petraru, Laura; Binder, Wolfgang H.

doi:10.1002/masy.200451320

Cited by 27 publications

(26 citation statements)

References 79 publications

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“…Recently, supramolecular polymers have attracted increasing attention because they exhibit some distinct advantages over covalent counterparts, such as fast and facile functionalization, reversibility, and self‐reparability,44–46 and potential applications to micro‐ and nanostructural materials such as nanorods47, 48 and porous polymer materials 49. The supramolecular polymers are usually constructed through noncovalent interactions, including hydrogen bond,50, 51 coordination bond,52 and ionic bond 53. The ionic bond is stronger than others53 and feasible to be obtained in comparison with coordination bond and multiple‐hydrogen bond, which may lead to its broad application.…”

Section: Introductionmentioning

confidence: 99%

Electron tomographic analysis of synaptic ultrastructure

Burette

Lesperance

Crum

et al. 2012

J of Comparative Neurology

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Synaptic function depends on interactions among sets of proteins that assemble into complex supramolecular machines. Molecular biology, electrophysiology, and live-cell imaging studies have provided tantalizing glimpses into the inner workings of the synapse, but fundamental questions remain regarding the functional organization of these “nano-machines.” Electron tomography reveals the internal structure of synapses in three dimensions with exceptional spatial resolution. Here we report results from an electron tomographic study of axospinous synapses in neocortex and hippocampus of the adult rat, based on aldehyde-fixed material stabilized with tannic acid in lieu of postfixation with osmium tetroxide. Our results provide a new window into the structural basis of excitatory synaptic processing in the mammalian brain.

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Section: Introductionmentioning

confidence: 99%

Electron tomographic analysis of synaptic ultrastructure

Burette

Lesperance

Crum

et al. 2012

J of Comparative Neurology

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“…Additionally, we have applied a simple mechanical model to explain material creep and shape-memory behavior.Over the last two decades, supramolecular polymers derived from small molecules or oligomers containing complementary H-bonding groups have been extensively studied and developed. [16][17][18] Since the strength of a single H-bond is small (∼ 20-40 kJ mol -1 ), multiple hydrogen bonding schemes are necessary to achieve selective, directional, and reversible binding of small molecule sub-units. Telechelic oligomers functionalized with ureidopyrimidinone (UPy) end-groups, for example, have been shown to undergo end-to-end association.…”

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confidence: 99%

Shape‐Memory Effects in Polymer Networks Containing Reversibly Associating Side‐Groups

et al. 2007

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“…Recently, supramolecular polymers have attracted increasing attention since they exhibit some distinct advantages over covalent counterparts, such as fast and facile functionalization, reversibility, and self‐reparability23–25 and potential applications to micro‐ and nanostructural materials such as nanorods26, 27 and porous polymer materials 28. The supramolecular polymers are usually constructed through noncovalent interactions, including hydrogen bond,29, 30 coordination bond,31 and ionic bond 32. The ionic bond is stronger than others32 and sensitive to pH alteration.…”

Section: Introductionmentioning

confidence: 99%

Left ventricular puncture: No frontier is risk free

Block

2010

Cathet Cardio Intervent

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Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is capable of measuring dilute labile protons and microenvironmental properties. However, the CEST contrast is dependent upon experimental conditions—particularly, the radiofrequency (RF) irradiation scheme. Although continuous‐wave RF irradiation has been used conventionally, the limited RF pulse duration or duty cycle of most clinical systems requires the use of pulsed RF irradiation. Here, the conventional numerical simulation is extended to describe pulsed‐CEST MRI contrast as a function of RF pulse parameters (i.e., RF pulse duration and flip angle) and labile proton properties (i.e., exchange rate and chemical shift). For diamagnetic CEST agents undergoing slow or intermediate chemical exchange, simulation shows a linear regression relationship between the optimal mean RF power of pulsed‐CEST MRI and continuous‐wave‐CEST MRI. The optimized pulsed‐CEST contrast is approximately equal to that of continuous‐wave‐CEST MRI for exchange rates less than 50 s−1, as confirmed experimentally using a multicompartment pH phantom. In the acute stroke animals, we showed that pulsed‐ and continuous‐wave‐amide proton CEST MRI demonstrated similar contrast. In summary, our study elucidated the RF irradiation dependence of pulsed‐CEST MRI contrast, providing useful insights to guide its experimental optimization and quantification. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.

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Synthesis and Self Assembly of Hydrogen‐Bonded Supramolecular Polymers

Cited by 27 publications

References 79 publications

Electron tomographic analysis of synaptic ultrastructure

Electron tomographic analysis of synaptic ultrastructure

Shape‐Memory Effects in Polymer Networks Containing Reversibly Associating Side‐Groups

Left ventricular puncture: No frontier is risk free

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