Synthesis and solution studies of ruthenium(II) complexes with thiazole and antileukaemic drug thiopurines. Crystal structure of trans-dichlorotris(1,3-thiazole)(triphenylphosphine)ruthenium(II) ‡

Kinetics and mechanism of the interaction of thioglycolic acid with [(H2O)(tap)2RuORu(tap)2(H2O)]2+ ion at physiological pH

“…The in vivo generation of mixed aqua-ammineruthenium(II) from the ruthenium(III) prodrug should be favoured in a relatively reducing and hypoxic environment provided by the interior of many tumours. Antitumour [14][15][16][17], antiherpes [18], anti-HIV [19], antiamebic [20], anticancer [21], antileucomic [22] and antifungal activity [23,24] are observed in a series of ruthenium complexes.…”

Kinetics and mechanism of the ligand substitution reaction between aquapentacyanoruthenate(II) and 4-cyanopyridine in the presence of anionic surfactant micelles

“…Ru(II/III) complexes have widespread use as antitumour [9], antimetastatic [10], antileukomic [11], anti-HIV [12] and antifungal [13,14] agents. The formation and complexation kinetics of [Ru(CN) 5 H 2 O] 3-in aqueous medium with some nitrogen heterocycles have been reported in the literature [15,16].…”

Kinetic and mechanistic studies on the interaction between glycylglycine and cis-diaqua-bis-(bipyridine)-ruthenium(II) complex in aqueous medium

“…The in vivo production of ruthenium(II) mixed aqua amine complex from ruthenium(III) prodrug should be favoured in relatively reducing and hypoxic environment provided by the interior of many tumours. Studies on a series of ruthenium complex show that many of them do exhibit antitumour [18][19][20][21], antiherpes [22], anti-HIV [23], antiamebic [24], anticancer [25], antileucemic [26] and antifungal [27] activity. This work describes the detailed kinetic and mechanistic studies of aqua ligand substitution from cis-[Ru(bipy) 2 (H 2 O) 2 ] 2+ (bipy = a a¢-bipyridine) by diglycine which is a model dipeptide.…”