Synthesis and some properties of 2-(polyfluoroalkyl)chroman-4-ols and 2-(polyfluoroalkyl)chroman-4-ones

Abstract

Reduction of 2 (polyfluoroalkyl)chromones by sodium borohydride in methanol gives cis 2 (polyfluoroalkyl)chroman 4 ols in high yields, which are easily oxidized by chromic acid to 2 (polyfluoroalkyl)chroman 4 ones. The latter are of interest as the starting materials for the preparation of novel R F containing chromane derivatives.

Efficient Rh-Catalyzed Chemo- and Enantioselective Hydrogenation of 2-CF3–Chromen/Thiochromen-4-ones

“…13 C­{ 1 H} NMR (150 MHz, chloroform- d ): δ 188.3, 159.4, 136.7, 127.1, 123.0 (q, J = 279.3 Hz), 122.8, 120.6, 117.9, 74.4 (q, J = 33.9 Hz), 36.1. 19 F NMR (376 MHz, chloroform- d ): δ −78.5 (s, 3F) …”

“…19 F NMR (376 MHz, chloroform-d): δ −78.5 (s, 3F). 23 (S)-7-Bromo-2-(trifluoromethyl)chroman-4-one (2b). CAS no.…”

Synthesis, Experimental and Theoretical Study of Azidochromones

“…Nitrenes and nitrenium ions can be generated from azides, which also serve as anchors for synthesis of nitrogen-rich compounds such as aziridines, azirines, triazoles, triazolines and triazides [9,15]. Different 2-trifluoromethyl and 2-(polyfluoroalkyl)chromones have been studied extensively [16][17][18][19]. Despite their ready accessibility, these compounds have been ignored by synthetic chemists, although their systematic study has been revitalized in recent years.…”