Synthesis and spectral studies on heterobimetallic complexes of manganese and ruthenium derived from N-(2-hydroxynaphthalen-1-yl)methylenebenzoylhydrazide

Singh, Mahesh Kumar; Kar, Nirmal K.; Lal, Ram A.; Asthana, Mrityunjaya

doi:10.1080/00958970902939822

Cited by 12 publications

(2 citation statements)

References 44 publications

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“…The diamagnetic complex (1) (d 6 , S = 0) showed two absorption bands at 444 and 612 nm that may arise from Ru(II)-to-ligand (MLCT) and d-d transitions, respectively [41]. The electronic spectra of the paramagnetic complex (2) (d 5 , S = 1 2 , µ eff = 1.70 µ B ), exhibits three absorption bands at 419, 498, and 699 nm due to LMCT and d-d transitions, consistent with low-spin octahedral geometry [41][42][43]. Electronic spectra of the ligand and its complexes are shown in Figure S4.…”

Section: Electronic Spectra and Magnetic Measurementsmentioning

confidence: 99%

Ruthenium(II)/(III) DMSO-Based Complexes of 2-Aminophenyl Benzimidazole with In Vitro and In Vivo Anticancer Activity

et al. 2020

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New anticancer ruthenium(II/III) complexes [RuCl2(DMSO)2(Hapbim)] (1) and [RuCl3(DMSO) (Hapbim)] (2) (Hapbim = 2-aminophenyl benzimidazole) have been synthesized and characterized, and their chemotherapeutic potential evaluated. The interaction of the compounds with DNA was studied by both UV-Visible and fluorescence spectroscopies, revealing intercalation of both the Hapbim ligand and the Ru complexes. The in vitro cytotoxicity of the compounds was tested on human breast cancer (MCF7), human colorectal cancer (Caco2), and normal human liver cell lines (THLE-2), with compound (2) the most potent against cancer cells. The cytotoxic effect of (2) is shown to correlate with the ability of the Ru(III) complex to induce apoptosis and to cause cell-cycle arrest in the G2/M phase. Notably, both compounds were inactive in the noncancerous cell line. The anticancer effect of (2) has also been studied in an EAC (Ehrlich Ascites Carcinoma) mouse model. Significantly, the activity of the complex was more pronounced in vivo, with removal of the cancer burden at doses that resulted in only low levels of hepatotoxicity and nephrotoxicity. An apoptosis mechanism was determined by the observation of increased Bax and caspase 3 and decreased Bcl2 expression. Furthermore, (2) decreased oxidative stress and increased the levels of antioxidant enzymes, especially SOD, suggesting the enhancement of normal cell repair. Overall, compound (2) shows great potential as a chemotherapeutic candidate, with promising activity and low levels of side effects.

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Section: Electronic Spectra and Magnetic Measurementsmentioning

confidence: 99%

Ruthenium(II)/(III) DMSO-Based Complexes of 2-Aminophenyl Benzimidazole with In Vitro and In Vivo Anticancer Activity

et al. 2020

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“…Coordination chemistry of transition metal complexes of iminophenol ligands derived from Schiff base condensation of substituted aniline and salicylaldehyde have been extensively studied over the last decades [1][2][3][4][5][6][7][8]. Schiff bases and their metal complexes have a variety of biological, clinical, analytical and industrial applications and they are playing an important role in catalysis organic synthesis [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, kinetic and thermodynamic parameters evaluation from TG-DTA analysis of Cu(II), Co(II) and Mn(II) complexes with two phenol Schiff bases

Abbas

2016

Eur. J. Chem.

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Complexes of Cu(II), Co(II) and Mn(II) with two Schiff base ligands {[(2-carboxyphenyl) imino]methyl} phenol (HLA) and {[(2-hydroxyphenyl)imino]methyl} phenol (HLB) were synthesized and characterized by FT-IR, UV-Visible, 1 H NMR spectroscopy and elemental analysis. All the synthesized complexes have been evaluated for their thermal degradation studies using TG-DTA analytical methods in static air. Thermodynamic and kinetic parameters were evaluated from the TG-DTA curves using Arrhenius equation.

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Synthesis, Characterization, and Fluorescence Chemosensor Properties of a cis‐Dioxomolybdenum(VI) Complex Containing Multidentate Hydrazone Ligands

Kurbah

Kumar

Shangpung

et al. 2017

Zeitschrift anorg allge chemie

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Synthesis and spectral studies on heterobimetallic complexes of manganese and ruthenium derived from N-(2-hydroxynaphthalen-1-yl)methylenebenzoylhydrazide

Cited by 12 publications

References 44 publications

Ruthenium(II)/(III) DMSO-Based Complexes of 2-Aminophenyl Benzimidazole with In Vitro and In Vivo Anticancer Activity

Ruthenium(II)/(III) DMSO-Based Complexes of 2-Aminophenyl Benzimidazole with In Vitro and In Vivo Anticancer Activity

Synthesis, characterization, kinetic and thermodynamic parameters evaluation from TG-DTA analysis of Cu(II), Co(II) and Mn(II) complexes with two phenol Schiff bases

Synthesis, Characterization, and Fluorescence Chemosensor Properties of a cis‐Dioxomolybdenum(VI) Complex Containing Multidentate Hydrazone Ligands

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