Synthesis and spectroscopic studies of potential anticancer [platinum(II)(2,2' -bipyridine)(amino acid)]n+ (n = 1 or 2) complexes

Kumar, Lalit; Kandasamy, N.R.; Srivastava, T.S.; Amonkar, A.J.; Adwankar, Manohar; Chitnis, M.P.

doi:10.1016/0162-0134(84)85001-1

Cited by 52 publications

(10 citation statements)

References 11 publications

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“…This value (154 M) is much higher as compared to the Ic 50 value of the above complex and lower than that of our analogous Pd (II) dithiocarbamate reported earlier [24]. The procedure for growth inhibition studies of the metal complex established that the DNA is the target biomolecule for this complex [30].…”

Section: Cytotoxicity Measurement Of the Pd(ii) Complexmentioning

confidence: 90%

Interaction studies between a 1,10-phenanthroline adduct of palladium(II) dithiocarbamate anti-tumor complex and calf thymus DNA. A synthesis spectral and in-vitro study

Mansouri‐Torshizi¹,

Saeidifar²,

Divsalar³

et al. 2010

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Section: Cytotoxicity Measurement Of the Pd(ii) Complexmentioning

confidence: 90%

Interaction studies between a 1,10-phenanthroline adduct of palladium(II) dithiocarbamate anti-tumor complex and calf thymus DNA. A synthesis spectral and in-vitro study

Mansouri‐Torshizi¹,

Saeidifar²,

Divsalar³

et al. 2010

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…Both complexes with DAA and DSA ligands exhibit IC 50 values comparable to cisplatin. The target molecule of the two complexes is suggested to be cells' DNA, because they selectively and persistently inhibit the rate of DNA synthesis (by reduced incorporation of [ 3 H]-thymidine in cells' DNA) [80]. The most probable mode for this class of dinuclear Pd(II) compounds seems to be hydrogen bonding in stabilizing the metal-DNA complexes.…”

Section: Two Novel Dinuclear Palladium Complexes {[Pd(en)cl] 2 (Bpsementioning

confidence: 99%

Metal Complexes with Aromatic N-Containing Ligands as Potential Agents in Cancer Treatment

Zhao¹,

Lin

2005

CMCACA

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Cisplatin (cis-Diamminedichloroplatinum(II)) is now clinically used as one of the most effective anticancer drugs in the treatment of a variety of human solid tumors, such as genitourinary. Unfortunately, its usefulness is limited due to development of resistance in tumor cells and its significant side effects. Thus, a continuing effort is being made to develop analogs to overcome the above shortcomings. However, direct structural analogs of cisplatin have not shown greatly improved clinical efficacy in comparison with the parent drug. The explanation for this finding is that all cis-[PtX(2)(amine)(2)] compounds have shown similar DNA-binding modes, thereby resulting in similar biological consequences. One approach is to look beyond structure-activity on the basis of cisplatin analogs antitumor agents, by identifying novel materials that can be utilized as building blocks. These may have DNA binding modes quite different from that of cisplatin. The introduction of such aromatic N-containing ligands as pyridine, imidazole and 1,10-phenanthroline, and their derivatives (whose donor properties are somewhat similar to the purine and pyrimidine bases) to antitumor agents is drawing attention. Many platinum and non-platinum metal complexes such as palladium, ruthenium, rhodium, copper, and lanthanum, with these aromatic N-containing ligands, have shown very promising antitumor properties in vitro and in vivo in cisplatin-resistant model systems or against cisplatin-insensitive cell lines. For example, one Ru(III) compound, [ImH][trans-Cl(4)(Me(2)SO)(Im)Ru(III)] (Im = imidazole, NAMI-A) successfully entered phase I clinical trials. In this review, medicinal chemistry, DNA binding modes, and the development status of these metal complexes are discussed.

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“…In Pt(II)Cl 2 histamine complex, histamine acts as a bidentate ligand coordinated to Pt(II) through the imidazole ring nitrogen (N 3 ) and the amino group (N a ) [26]. Similar type of coordination is also observed for platinum-histidine complexes [33,34]. Thus, chelation of platinum(IV) by two histamine molecules coordinated through two donor nitrogen atoms (N 3 , N a ) from each histamine molecule seems evident.…”

Section: Characterisation Of the Pt(iv)(histamine) 2 Complexmentioning

confidence: 77%

Synthesis and preliminary evaluation of the new water-soluble radioactive platinum(IV) complexes

Garnuszek

Maurin

Skierski

et al. 2004

Journal of Inorganic Biochemistry

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Synthesis and spectroscopic studies of potential anticancer [platinum(II)(2,2' -bipyridine)(amino acid)]n+ (n = 1 or 2) complexes

Cited by 52 publications

References 11 publications

Interaction studies between a 1,10-phenanthroline adduct of palladium(II) dithiocarbamate anti-tumor complex and calf thymus DNA. A synthesis spectral and in-vitro study

Interaction studies between a 1,10-phenanthroline adduct of palladium(II) dithiocarbamate anti-tumor complex and calf thymus DNA. A synthesis spectral and in-vitro study

Metal Complexes with Aromatic N-Containing Ligands as Potential Agents in Cancer Treatment

Synthesis and preliminary evaluation of the new water-soluble radioactive platinum(IV) complexes

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