Synthesis and Structural Characterization of Zinc and Magnesium Doped Hydroxyapatite

Abstract

Zn or Mg ions doped hydroxyapatite (HA) particles were successfully developed by introducing various concentration of Zn or Mg in the starting solution using wet chemical precipitation method and followed a hydrothermal treatment. The products were identified as HA by XRD and FTIR, and the precipitated particles had a rod-like morphology. All the products for Mg and Zn ions concentration in the preparation solution less than 40 mol% were identified as HA. Substitution of Mg and Zn in HA crystal would impair the crystallization of HA and significantly reduce the length of a, c values of HA unit cell, which clearly demonstrated that Mg or Zn ions were structurally incorporated into the apatite crystals, they were not just absorbed on the surface of crystals.

Synthesis and Structural Characteristics of Magnesium and Zinc Doped Hydroxyapatite Whiskers

“…Substitution of Mg in HA crystals obviously reduced the crystallinity of HA whiskers and both the a and c values of HA unit cell, especially for that of HA crystals doped with ≥ 8 % Mg, which was coincident with the previous reports [19,20]. However, the changes in the lattice parameters for Zn doped HA did not show any regularity, the a value increased when the doping concentration was > 5 %, but the c value nearly remained a constant value, which was consistent with the finding of Miyaji [16], who reported that the lattice parameter a decreased up to 5 mol.…”

“…With the increase of Mg or Zn concentration in the initial synthesis solution, both the length and aspect ratio were impaired. For the proportion of Mg ions of > 15 %, few second phases appeared in the products, they were identified as Ca 19 13.80 . Therefore, the appropriate starting concentration of these ions in HA whiskers should be less than 10 mol.…”

The relative stabilities of A- and B-type carbonate substitution in apatites synthesized in aqueous solution

“…Few studies have focused on the carbonate asymmetric stretching region of the IR spectra of Zn or Mg-doped apatites. Peaks obtained during characterization of Zn apatites include those at 1416 and 1465 cm −1 for an apatite with 0.01 mole Zn relative to 9.99 mole calcium (Fadeeva et al, 2012), peaks at 1429 and 1454 cm −1 for both Mg-and Zn-doped apatites with ∼5% dopant (Zhang et al, 2013), and peaks in the regions 1430-1433 cm −1 and 1458-1468 cm −1 for fluorapatites containing a 1:3 mole ratio of Mg to Ca (Peld et al, 1994). As shown in Fig.…”

Structural Analysis and Characterization of Cu, Sr-doped Hydroxyapatite Whiskers

“…Synthetic HA has been gradually accepted and widely used to repair bone and tooth defects due to its similarity with the composition of human hard tissue [1,2].…”