Synthesis and Structural Characteristics of Magnesium and Zinc Doped Hydroxyapatite Whiskers

Zhang, Hongquan

doi:10.13168/cs.2017.0022

Cited by 13 publications

(10 citation statements)

References 19 publications

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“…Previous studies regarding magnesium-doped hydroxyapatite have revealed that Mg ions inhibited the HAp crystallization in solution, and also that Mg in high concentrations could destabilize the structure of HAp [35,36]. Furthermore, studies have emphasized that Mg addition exhibited an inhibitory effect on HAp nucleation, its crystal growth, and also that Mg in high concentration causes a significant reduction in crystallinity coupled with an increase of its dissolution [37,38,39,40,41]. The complex investigation study of physico-chemical properties of hydroxyapatite doped with magnesium in solution [2,3,9,14,17] are rather limited.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

et al. 2019

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Obtaining nanoscale materials has allowed for the miniaturization of components, which has led to the possibility of achieving more efficient devices with faster functions and much lower costs. While hydroxyapatite [HAp, Ca10(PO4)6(OH)2] is considered the most widely used material for medical applications in orthopedics, dentistry, and general surgery, the magnesium (Mg) is viewed as a promising biodegradable and biocompatible implant material. Furthermore, Mg is regarded as a strong candidate for developing medical implants due to its biocompatibility and antimicrobial properties against gram-positive and gram-negative bacteria. For this study, magnesium-doped hydroxyapatite (Ca10−xMgx (PO4)6 (OH)2, xMg = 0.1), 10MgHAp, suspensions were successfully obtained by an adapted and simple chemical co-precipitation method. The information regarding the stability of the nanosized 10MgHAp particles suspension obtained by ζ-potential analysis were confirmed for the first time by a non-destructive ultrasound-based technique. Structural and morphological studies of synthesized 10MgHAp were conducted by X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy in attenuated total reflectance (ATR) mode and scanning electron microscopy (SEM). The XRD analysis of the 10MgHAp samples confirmed that a single crystalline phase associated to HAp with an average grain size about 93.3 nm was obtained. The FTIR-ATR spectra revealed that the 10MgHAp sample presented broader IR bands with less visible peaks when compared to a well-crystallized pure HAp. The SEM results evidenced uniform MgHAp nanoparticles with spherical shape. The antimicrobial activity of the 10MgHAp suspension against gram-positive strains (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212), gram-negative strains (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), as well as a fungal strain (Candida albicans ATCC 90029) were evaluated.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

et al. 2019

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“…Nonetheless, there are several emerging cations with both antimicrobial properties and important roles in the enhancement of the biological interactions of HAp with the surrounding tissues, amid which Mg 2+ comes into prominence [28][29][30]. Magnesium is one of the most important essential trace elements, being involved in the development of bones and connective tissues and possessing osteogenic and angiogenic stimulating properties, demonstrated both in vitro and in vivo [31][32][33][34][35]. Moreover, it has been reported that this specific trace element plays a significant role in the bone calcification process, influencing the osteoblast and osteoclast activities [32].…”

Section: Introductionmentioning

confidence: 99%

Dextran-Thyme Magnesium-Doped Hydroxyapatite Composite Antimicrobial Coatings

et al. 2020

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The dextran-thyme magnesium-doped hydroxyapatite (10MgHAp-Dex-thyme) composite layers were prepared by a dip-coating procedure from stable suspensions and further analyzed for the first time. Different characterization techniques were employed to explore the physical-chemical features of the 10MgHAp-Dex-thyme suspensions and derived coatings. Information regarding the 10MgHAp-Dex-thyme suspensions was extracted on the basis of dynamic light scattering, zeta potential, and ultrasound measurements. The crystalline quality of the biocomposite powders—resulting after the centrifugation of suspensions—and the layers deposited on glass was assessed by X-ray diffraction in symmetric and grazing incidence geometries, respectively. The chemical structure and presence of functional groups were evaluated for both powder and coating by Fourier transform infrared spectroscopy in attenuated total reflectance mode. The extent of the antimicrobial effect range of the biocomposite suspensions and coatings was tested against different Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa) and fungus (Candida albicans) strains with promising results.

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“…30,31 Increased cell unit parameters are justifiable in consideration of enhanced content of lattice H 2 O confirmed with FTIR peaks at 3570-3572 cm -1 . 32 At a higher level of Cu incorporation (7% wt), dehydroxylation of materials might lead to a small decrease in a parameter expansion. 33 XRD spectra demonstrated the existence of nHA, Cs, and Gel components within scaffolds.…”

Section: Discussionmentioning

confidence: 99%

Fabrication, characterization, and optimization of a novel copper-incorporated chitosan/gelatin-based scaffold for bone tissue engineering applications

et al. 2021

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Introduction: Fabricating composite scaffolds with improved physicochemical properties as artificial microenvironments are of great interest in bone tissue engineering. Given advantageous properties of nano-hydroxyapatite/chitosan/gelatin (nHA/Cs/Gel) scaffolds, the present study aimed to synthesize a modified nHA/Cs/Gel biomimetic scaffold with improved features. Methods: Pure and copper (Cu)-substituted nHA was synthesized using the chemical precipitation method under controlled pH and temperature. Pure and Cu-substituted nHA/Cs/Gel scaffolds were fabricated by salt-leaching/freeze-drying method. Physicochemical characteristics of nanoparticles and scaffolds were explored using XRD, FTIR, FE-SEM/EDX, and ICP. Besides, scaffold mechanical strength, degradation, porosity, swelling, biomineralization, and cytocompatibility were assessed. Results: Pure and Cu-substituted nHA were synthesized and characterized with appropriate Cu substitution and improved physical properties. All scaffolds were highly porous (porosity >98%) and Cu incorporation reduced porosity from 99.555 ± 0.394% to 98.69 ± 0.80% while enlarged the pore size to more than100 µm. Cu-substitution improved the scaffold mechanical strength and the best result was observed in nHA.Cu5%/Cs/Gel scaffolds by the compressive strength 88.869 ± 19.574 MPa. Furthermore, 3% and 5% Cu-substituted nHA enhanced the scaffold structural stability and supported osteoblast spread, adhesion, survival, mineralization, and proliferation. Moreover, long-term and sustainable Cu release from scaffolds was observed within 28 days. Conclusion: Cu-substituted nHA/Cs/Gel scaffolds mimic the porous structure and mechanical strength of cancellous bone, along with prolonged degradation and Cu release, osteoblast attachment, viability, calcium deposition, and proliferation. Taken together, our results indicate the upgraded properties of nHA.Cu5%/Cs/Gel scaffolds for future applications in bone tissue engineering.

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Synthesis and Structural Characteristics of Magnesium and Zinc Doped Hydroxyapatite Whiskers

Abstract: Mg and Zn doped hydroxyapatite whiskers were successfully prepared by hydrothermal homogeneous precipitation using amide additives. The morphology and structure of the products were characterized using SEM, XRD, and FTIR. It

Cited by 13 publications

References 19 publications

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

Synthesis, Characterization, and Antimicrobial Activity of Magnesium-Doped Hydroxyapatite Suspensions

Dextran-Thyme Magnesium-Doped Hydroxyapatite Composite Antimicrobial Coatings

Fabrication, characterization, and optimization of a novel copper-incorporated chitosan/gelatin-based scaffold for bone tissue engineering applications

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