Synthesis and Structure Elucidation of Novel Oxime Ether Type H/K+-ATPase Inhibitors

Jin, Lei; Fang, Hu Biao; Huang, Nianyu; Wang, Jun Zhi; Zou, Kun

doi:10.4028/www.scientific.net/amr.746.40

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“…The test compounds were dissolved in ethanol (initial concentration 10 mg/mL), and diluted with 1640 medium to different concentrations of 0~100 mg/L. The H + /K + -ATPase inhibitory activity was determined by H + /K + -ATPase kits according to our previous methods [10,11]. All data were presented as mean ± standard deviation and analyzed by SPSS.…”

Section: Synthesismentioning

confidence: 99%

Synthesis and Characterization of Triazole-Linked Bistetrahydrobenzofuran Derivatives as Anti-Ulcer Agents

Yang

Chen

et al. 2014

AMR

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A pair of triazole-linked bistetrahydrobenzofuran derivatives were prepared in high yields through Cu (II)-catalyzed click reaction under mild conditions. All of the intermediates and target compounds were characterized by NMR, IR, ESI-MS and elemental analysis. Thein vitroH+/K+-ATPase inhibitory effect for the target compounds were also evaluated by MTT methods, and the (E)-isomer of the bistetrahydrobenzofurans exhibited the better H+/K+-ATPase inhibitory activities than the commercial omeprazole with the IC50of 37.90 μM. The bioactive compound might be potentially used as anti-ulcer agents in the treatment of acid-related diseases.

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Section: Synthesismentioning

confidence: 99%