Synthesis and structure elucidation of new open cubane tetranuclear [Cu II 4 ] Cluster: Evaluation of the DNA/HSA interaction and pBR322 DNA cleavage pathway and cytotoxicity

Tabassum, Sartaj; Afzal, Mohammad; Al‐Lohedan, Hamad A.; Zaki, Mehvash; Khan, Rais Ahmad; Ahmad, Musheer

doi:10.1016/j.ica.2017.04.031

Cited by 10 publications

(5 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The distances of the oxygen atoms in the 3 -and 2 -bridging positions to the copper atoms are assymmetrical with Cu1-O26 i , Cu1-O26 and Cu2-O26 distances of 2.4280 14, 1.9684 (13), 1.9707 14Å , respectively, while Cu1-O15 and Cu2-O15 are 1.9170 (13) and 1.9324 (13) Å , respectively (Table 4). These distances agree with those in related structures (Lazarou et al, 2018;Tabassum et al, 2017). The environment of both Cu II cations is again best described as distorted square pyramidal.…”

Section: Figuresupporting

confidence: 85%

Crystal structures of two Cu^II compounds: catena-poly[[chloridocopper(II)]-μ-N-[ethoxy(pyridin-2-yl)methylidene]-N′-[oxido(pyridin-3-yl)methylidene]hydrazine-κ⁴ N,N′,O:N′′] and di-μ-chlorido-1:4κ² Cl:Cl-2:3κ² Cl:Cl-dichlorido-2κCl,4κCl-bis[μ₃-ethoxy(pyridin-2-yl)methanolato-1:2:3κ³

Sall

Tamboura

et al. 2019

Acta Cryst E

View full text Add to dashboard Cite

Two CuII complexes [Cu(C14H13N4O2)Cl] n , I, and [Cu4(C8H10NO2)4Cl4] n , II, have been synthesized. In the structure of the mononuclear complex I, each ligand is coordinated to two metal centers. The basal plane around the CuII cation is formed by one chloride anion, one oxygen atom, one imino and one pyridine nitrogen atom. The apical position of the distorted square-pyramidal geometry is occupied by a pyridine nitrogen atom from a neighbouring unit, leading to infinite one-dimensional polymeric chains along the b-axis direction. Each chain is connected to adjacent chains by intermolecular C—H...O and C—H...Cl interactions, leading to a three-dimensional network structure. The tetranuclear complex II lies about a crystallographic inversion centre and has one core in which two CuII metal centers are mutually interconnected via two enolato oxygen atoms while the other two CuII cations are linked by a chloride anion and an enolato oxygen. An open-cube structure is generated in which the two open-cube units, with seven vertices each, share a side composed of two CuII ions bridged by two enolato oxygen atoms acting in a μ3-mode. The CuII atoms in each of the two CuO3NCl units are connected by one μ2-O and two μ3-O atoms from deprotonated hydroxyl groups and one chloride anion to the three other CuII centres. Each of the pentacoordinated CuII cations has a distorted NO3Cl square-pyramidal environment. The CuII atoms in each of the two CuO2NCl2 units are connected by μ2-O and μ3-O atoms from deprotonated alcohol hydroxy groups and one chloride anion to two other CuII ions. Each of the pentacoordinated CuII cations has a distorted NO2Cl2 square-pyramidal environment. In the crystal, a series of intramolecular C—H...O and C—H...Cl hydrogen bonds are observed in each tetranuclear monomeric unit, which is connected to four tetranuclear monomeric units by intermolecular C—H...O hydrogen bonds, thus forming a planar two-dimensional structure in the (\overline{1}01) plane.

show abstract

Section: Figuresupporting

confidence: 85%

Crystal structures of two Cu^II compounds: catena-poly[[chloridocopper(II)]-μ-N-[ethoxy(pyridin-2-yl)methylidene]-N′-[oxido(pyridin-3-yl)methylidene]hydrazine-κ⁴ N,N′,O:N′′] and di-μ-chlorido-1:4κ² Cl:Cl-2:3κ² Cl:Cl-dichlorido-2κCl,4κCl-bis[μ₃-ethoxy(pyridin-2-yl)methanolato-1:2:3κ³

Sall

Tamboura

et al. 2019

Acta Cryst E

View full text Add to dashboard Cite

show abstract

“…We demonstrate that complex 1 oxidatively cleaves DNA, even in the absence of a coreactant (reducing agent), a similar effect was previously shown by our group and in the literature − unlike several other copper complexes that require external agents to promote activity. − To fully assess the hypothesis that 1 acts by an oxidative mechanism, we carried out assays to analyze the influence of dissolved molecular oxygen in the cleavage process. Parallel reactions in aerobic or anaerobic conditions (argon atmosphere) were prepared.…”

supporting

confidence: 78%

Targeting an Artificial Metal Nuclease to DNA by a Simple Chemical Modification and Its Drastic Effect on Catalysis

Castilho

Gabriel

Camargo

et al. 2019

ACS Med. Chem. Lett.

View full text Add to dashboard Cite

A novel metal complex was synthesized containing a purine derived ligand in order to increase its binding to DNA. We observed a huge increase in nuclease activity and, quite interestingly, an improvement on DNA sequence selectivity. A potential site of specific cleavage in the presence of a reductant in the reaction medium is suggested. We were able to synthesize a novel metal nuclease with improved activity on DNA, and with sequence specificity when exposed to a coreactant, this opens up new possibilities to create site specific and redox status modulated artificial nucleases.

show abstract

“…Cu‐55 showed significant nuclease activity causing single‐strand breaks, confirming the contribution of ROS. The interaction of Cu‐55 with HSA and DNA was confirmed by molecular docking studies [82] …”

Section: Complexes With Tridentate Schiff Bases O N O With Metals Of ...mentioning

confidence: 79%

“…The interaction of Cu-55 with HSA and DNA was confirmed by molecular docking studies. [82] A year later, Usman et al synthesized the tetranuclear copper(II) coordination complexes Cu-56 and Cu-57. The first compound showed a classic closed Cu 4 O 4 cubane structure, while the second compound showed a less common open Cu 4 O 4 cubane structure.…”

Section: Chemmedchemmentioning

confidence: 99%

Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

et al. 2022

View full text Add to dashboard Cite

Although it is known that the first case of cancer was recorded in ancient Egypt around 1600 BC, it was not until 1917 during the First World War and the development of mustard gas that chemotherapy against cancer became relevant; however, its properties were not recognised until 1946 to later be used in patients. In this sense, the use of metallopharmaceuticals in cancer therapy was extensively explored until the 1960s with the discovery of cisplatin and its anticancer activity. From that date to the present, the search for more effective, more selective metallodrugs with fewer side effects has been an area of continuous exploration. Efforts have led to considering a wide variety of metals from the periodic table, mainly from the d-block, as well as a wide variety of organic ligands, preferably with proven biological activity. In this sense, various research groups have found an ideal binder in Schiff bases, since their raw materials are easily accessible, their synthesis conditions are friendly and their denticity can be manipulated. Therefore, in this review, we have explored the anticancer and antitumor activity reported in the literature for coordination complexes of d-block metals coordinated with tridentate Schiff bases (O N O and O N N) derived from salicylaldehyde. For this work, we have used the main scientific databases CCDC® and SciFinder®.

show abstract

Synthesis and structure elucidation of new open cubane tetranuclear [Cu II 4 ] Cluster: Evaluation of the DNA/HSA interaction and pBR322 DNA cleavage pathway and cytotoxicity

Cited by 10 publications

References 59 publications

Targeting an Artificial Metal Nuclease to DNA by a Simple Chemical Modification and Its Drastic Effect on Catalysis

Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

Contact Info

Product

Resources

About

Synthesis and structure elucidation of new open cubane tetranuclear [Cu II 4 ] Cluster: Evaluation of the DNA/HSA interaction and pBR322 DNA cleavage pathway and cytotoxicity

Cited by 10 publications

References 59 publications

Crystal structures of two CuII compounds: catena-poly[[chloridocopper(II)]-μ-N-[ethoxy(pyridin-2-yl)methylidene]-N′-[oxido(pyridin-3-yl)methylidene]hydrazine-κ4 N,N′,O:N′′] and di-μ-chlorido-1:4κ2 Cl:Cl-2:3κ2 Cl:Cl-dichlorido-2κCl,4κCl-bis[μ3-ethoxy(pyridin-2-yl)methanolato-1:2:3κ3

Crystal structures of two CuII compounds: catena-poly[[chloridocopper(II)]-μ-N-[ethoxy(pyridin-2-yl)methylidene]-N′-[oxido(pyridin-3-yl)methylidene]hydrazine-κ4 N,N′,O:N′′] and di-μ-chlorido-1:4κ2 Cl:Cl-2:3κ2 Cl:Cl-dichlorido-2κCl,4κCl-bis[μ3-ethoxy(pyridin-2-yl)methanolato-1:2:3κ3

Targeting an Artificial Metal Nuclease to DNA by a Simple Chemical Modification and Its Drastic Effect on Catalysis

Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

Contact Info

Product

Resources

About