Synthesis and structure of a new tetracopper(II) complex withN-benzoate-N′-[2-(2-hydroxyethylamino)ethyl]oxamide as bridging ligand:in vitroanticancer activities and DNA- and BSA-binding studies

Xing, Ting-Ting; Zhan, Shuai; Li, Yan‐Tuan; Wu, Zhi‐Yong; Yan, Cui‐Wei

doi:10.1080/00958972.2013.827179

Cited by 21 publications

(4 citation statements)

References 73 publications

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“…IC 50 values of 2 and 3 reach about 10 μM, lower than that of some previously reported analogous copper(II) complexes against these human alimentary system carcinoma cell lines [18][19][20][33][34][35][36], indicating that 2 and 3 have potent cytotoxicity.…”

Section: Copper(ii) Complexes 2353mentioning

confidence: 51%

Cytotoxicity towards human alimentary system carcinoma cells resulting from diverse copper(II) complexes

Zhao

Peng

Guo

et al. 2014

Journal of Coordination Chemistry

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To investigate the potential cytotoxicity of copper(II)-based complexes, three coordination compounds with heterocyclic ligands, Cu(pbmbt)Cl 2 (CH 3 OH) (1), Cu 2 (ddbib) 2 (NO 3 ) 4 ·3CH 3 OH (2), and Cu 3 (ttmtmb) 2 Cl 6 ·2.5H 2 O (3), which include mononuclear, dinuclear, and trinuclear structures, have been synthesized from reactions of corresponding copper(II) salts with 1-imidazole (ddbib), and 1,1′,1′′-((2,4,6-trimethylbenzene-1,3,5-triyl)tris(methylene)tris(2-methyl-1H-benzoimidazole) (ttmtmb), respectively. IC 50 values revealed that 2 and 3 show strong cytotoxicity, whereas 1 is weakly cytotoxic after being tested against a panel of several human alimentary system carcinoma cell lines (SGC7901, EC109, SMMC7721, and HT29). The number of copper centers and different structures could make a tremendous difference on their cytotoxicity. Three coordination compounds with heterocyclic ligands were constructed to investigate the potential cytotoxicity of copper(II)-based complexes. IC 50 values revealed that complexes 2 and 3 show strong cytotoxicity, whereas complex 1 is weakly cytotoxic after being tested by MTT assay against a panel of several human alimentary system carcinoma cell lines.

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Section: Copper(ii) Complexes 2353mentioning

confidence: 51%

Cytotoxicity towards human alimentary system carcinoma cells resulting from diverse copper(II) complexes

Zhao

Peng

Guo

et al. 2014

Journal of Coordination Chemistry

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“…We also compared the DNA-binding properties of 1 with those of previously reported polycopper(II) complexes with various bridging ligands and polypyridines as terminal ligands [48][49][50][51], and we find that not only the interaction modes but also the DNA-binding ability of these polycopper(II) complexes are different, suggesting that interactions of these complexes toward DNA may be tuned by changing the bridging or terminal ligands. Such strategy should be valuable in designing new polynuclear complex systems and understanding the binding between these polynuclear complexes and DNA.…”

Section: Dna Interaction Studiesmentioning

confidence: 96%

Synthesis and structure of a 1-D copper(II) coordination polymer bridged both by oxamido and carboxylate: in vitro anticancer activity and reactivity toward DNA and protein BSA

Zheng

et al. 2015

Journal of Coordination Chemistry

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2015) Synthesis and structure of a 1-D copper(II) coordination polymer bridged both by oxamido and carboxylate: in vitro anticancer activity and reactivity toward DNA and protein BSA, Journal of Coordination Chemistry, 68:5, 928-948, A new 1-D copper(II) coordination polymer was synthesized and structurally characterized. In vitro anticancer activity and reactivity toward DNA and protein of the copper(II) polymer was studied.A 1-D copper(II) coordination polymer formulated as {[Cu 2 (bdpox)(dabt)](NO 3 )·H 2 O} n , where H 3 bdpox and dabt denote N-benzoate-N′-[3-(diethylamino)propyl]oxamide and 2,2′-diamino-4,4′-bithiazole, respectively, was synthesized and characterized by elemental analyses, molar conductance *Corresponding authors.Downloaded by [University of Saskatchewan Library] at 07:16 17 March 2015 measurement, IR and electronic spectra studies, and single-crystal X-ray diffraction. The crystal structure analysis reveals that copper(II) ions are bridged by both cis-oxamido and carboxylato groups to form a 1-D coordination polymer with corresponding Cu···Cu separations of 5.2420(10) and 5.1551(8) Å. The endo-and exo-copper(II) ions of the cis-oxamido-bridge are located in distorted square-planar and square-pyramidal geometries, respectively. There is a 2-D hydrogen bonding network in the crystal. The in vitro anticancer activities suggest that the copper(II) complex is active against selected tumor cell lines. The reactivities toward herring sperm DNA and bovine serum albumin (BSA) reveal that the copper(II) complex can interact with DNA by intercalation and effectively quench the intrinsic fluorescence of BSA via a static mechanism. The influence of hydrophobicity of the substituents in bridging ligands on DNA and protein binding properties and the in vitro anticancer activities of such copper(II) polymers is discussed.

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“…It is sometimes very important to study the interaction of a bioactive compound with proteins, to gain fundamental insights of the binding mechanism and to understand the metabolism and transporting process of a drug compound. Therefore, to understand the protein binding activities of the cluster compound 10, BSA was used to study the tryptophan emissionquenching experiment [34]. Generally, the fluorescence of BSA is caused by three intrinsic characteristics of the protein, namely tryptophan, tyrosine and phenylalanine.…”

Section: Bsa Protein Binding Studiesmentioning

confidence: 99%

Synthesis, structure and antibacterial activity of ferrocenyl diphopshine chelated iron – telluride cluster

Tirkey

Boddhula

Mishra

et al. 2015

Journal of Organometallic Chemistry

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Synthesis and structure of a new tetracopper(II) complex withN-benzoate-N′-[2-(2-hydroxyethylamino)ethyl]oxamide as bridging ligand:in vitroanticancer activities and DNA- and BSA-binding studies

Cited by 21 publications

References 73 publications

Cytotoxicity towards human alimentary system carcinoma cells resulting from diverse copper(II) complexes

Cytotoxicity towards human alimentary system carcinoma cells resulting from diverse copper(II) complexes

Synthesis and structure of a 1-D copper(II) coordination polymer bridged both by oxamido and carboxylate: in vitro anticancer activity and reactivity toward DNA and protein BSA

Synthesis, structure and antibacterial activity of ferrocenyl diphopshine chelated iron – telluride cluster

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