Synthesis and Structure of New Pyrido[2,3-d]pyrimidine Derivatives with Calcium Channel Antagonist Activity

One-Pot Synthesis of Novel Derivatives of Dithioxopyrido[2,3-d:6,5-d’]dipyrimidine-4,6-diones Using Hap-Encapsulated γ-Fe2O3 Supported Sulfonic Acid Nanocatalyst

“…In particular, the synthesis of pyridopyrimidine and their derivatives remains of great interest in organic chemistry, because some of them exhibit significant biological and pharmacological activities, such as antifolate activity [16], antibacterial activity [17], tyrosine kinase activity [18], antimicrobial activity [19], calcium channel antagonists activity [20], anti-inflammatory and analgesic activity [21], antileishmanial activity [22], tuber-culostatic activity [23], anticonvulsants activity [24], diuretic and potassium-sparing activity [25], antiaggressive activity [26], and antitumor activity [27].…”

An Efficient Synthesis of Pyrido[2,3-<i>d</i>]pyrimidine Derivatives via One-Pot Three-Component Reaction in Aqueous Media

“…The importance of pyridopyrimidines as biologically active compounds includes their use as antibacterial [1][2][3], antiallergic [4], antitumor [2,3] antifolate [5], tyrosine kinase [6], antimicroibial [7], calcium channel antagonists [8], antibacterial [9][10][11][12], anti-inflammatory, analgesic [13], antihypertensive [14], antileishmanial [15], tuber-culostatic [16], anticonvulsants [17], diuretic, potassiumsparing [18], and antiaggressive activities [19]. The need to reduce the amount of toxic waste and byproduct arising from chemical processes requires increasing emphasis on the use of less toxic and environmentally compatible materials in the design of new synthetic methods.…”

Synthesis and Spectral Analysis of an Array of Novel 4-(4-Morpholinophenyl)-6-Aryl-Pyrimidin-2-Amines

“…Some notable biological activity of pyrimidine derivatives include adenosine receptor antagonists [1], kinase inhibitors [2], analgesic [3], anti-inflammatory [3], inhibitors of cyclin-Dependent kinases 1 and 2 [4], calcium channel antagonist [5], antihistaminic [6], antitubercular [7] activities. Substituted aminopyrimidine nuclei are common in marketed drugs such as anti-atherosclerotic aronixil, anti-histaminic thonzylamine, anti-anxielytic buspirone, anti-psoriatic enazadrem, and other medicinally relevant compounds.…”