Synthesis and study of antimicrobial activity of 4-amino-1,2,4-triazolo[5,1-c][1,2,4]triazine derivatives against Neisseria gonorrhoeae

Bersneva, E. V.; Voinkov, E. K.; Drokin, R. A.; Gerasimova, N. A.; Evstigneeva, N. P.; Zilberberg, N. V.; Kungurov, N. V.; Rusinov, V. L.

doi:10.1007/s11172-023-4113-6

Russ Chem Bull

2023

DOI: 10.1007/s11172-023-4113-6

|View full text |Cite

Synthesis and study of antimicrobial activity of 4-amino-1,2,4-triazolo[5,1-c][1,2,4]triazine derivatives against Neisseria gonorrhoeae

E. V. Bersneva,

E. K. Voinkov,

R. A. Drokin

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Determination of pK_a of triazolo[5,1-c][1,2,4]triazines in non-aqueous media by potentiometric titration

Ivoilova,

Mozharovskaia,

Mokrousova

et al. 2024

Chim.Tech.Acta

View full text Add to dashboard Cite

In this work, for the first time, an approach was suggested for determining the pKa of triazolo[5,1-c][1,2,4]triazine compounds in N,N-dimethylformamide using potentiometric titration. It was noted that change in system potential in the titration curves of triazolo[5,1-с][1,2,4]triazine are observed for compounds containing either H+ located at the nitrogen atom in position 1 or an –NH2 group. The calculated pKa values of the studied molecules correspond to the pKa values of moderately strong acids and are in the range of 2–8. The relationship was established between the acidity of the heterocyclic fragment and the presence of electron donor substituents. The obtained pKa values of the compounds correlate with the calculated possible deprotonation centers of the molecule. It was found that determining the acidity constants of substances is useful for clarifying the mechanisms of their transformations. The possibility of establishing a relationship between the structure of the compound, pKa, and probable biological activity was shown.

show abstract

Determination of pK_a of triazolo[5,1-c][1,2,4]triazines in non-aqueous media by potentiometric titration

Ivoilova,

Mozharovskaia,

Mokrousova

et al. 2024

Chim.Tech.Acta

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Synthesis and study of antimicrobial activity of 4-amino-1,2,4-triazolo[5,1-c][1,2,4]triazine derivatives against Neisseria gonorrhoeae

Cited by 1 publication

References 19 publications

Determination of pK_a of triazolo[5,1-c][1,2,4]triazines in non-aqueous media by potentiometric titration

Determination of pK_a of triazolo[5,1-c][1,2,4]triazines in non-aqueous media by potentiometric titration

Contact Info

Product

Resources

About

Synthesis and study of antimicrobial activity of 4-amino-1,2,4-triazolo[5,1-c][1,2,4]triazine derivatives against Neisseria gonorrhoeae

Cited by 1 publication

References 19 publications

Determination of pKa of triazolo[5,1-c][1,2,4]triazines in non-aqueous media by potentiometric titration

Determination of pKa of triazolo[5,1-c][1,2,4]triazines in non-aqueous media by potentiometric titration

Contact Info

Product

Resources

About

Determination of pK_a of triazolo[5,1-c][1,2,4]triazines in non-aqueous media by potentiometric titration

Determination of pK_a of triazolo[5,1-c][1,2,4]triazines in non-aqueous media by potentiometric titration