Synthesis and study of new paramagnetic resveratrol analogues

Facile syntheses of 3,4-disubstituted pyrroline nitroxides and their further synthetic applications

“…17 These reactions can also be conducted in the presence of nitroxide free radicals. 10,12,13 Thus, we hypothesized that halogenated vinylnitroxides, as well as paramagnetic boronic acids or trialkyl-stan-80 nanes could be partners in these cross-coupling reactions. Therefore we attempted C-Sn and C-B forming reactions ( group that was introduced.…”

“…It is crucial to be able to carry out C-C bond forming reactions in the presence of ambiphilic nitroxide free radicals without compound degradation. The application of the Pd-catalyzed cross-coupling reactions such as the Suzuki, 10,12 Heck, 13 and Sonogashira 12 reactions has simplified this problem.…”

“…Over the last two decades, the syntheses of 3,4-disubstituted pyrroline nitroxides including Pd-catalyzed cross-coupling reactions were reported by our laboratory. 12,13 However, many of these approaches demonstrate reactivity for a limited number of substrates, have low yields, and require multistep reactions. In this paper we report a simple methodology for the synthesis of 3,4-disubstituted pyrroline nitroxides, by con-60 structing new C-B, C-C, C-S, C-Sn, and C-I bonds starting from readily available methyl 1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-carboxylate radical (1).…”

“…Supplementary data (experimental procedures, physical and spectroscopic data, a scheme illustrating an earlier procedure and copies of 1 H and 13 C NMR spectra of selected compounds) associated with this article can be found, in the online version, at http://dx.doi.org/10.1016/j.tetlet.2016.01.012.…”

Synthesis, Characterization and Antibacterial Evaluation of some Novel Benzimidazole Derivatives Containing 1,3,4-Thiadiazole Moiety.

“…1,2 Benzimidazole ring count a significant heterocyclic pharmacophore in the drug discovery, these compounds which carrying diverse substituents in the structure of benzimidazole are associated with a wide range of biological activities including: antifungal, 3,4,5 anticancer, 6,7,8 antiinflammatory, 9,10 antioxidant, 11,12,13 anti-bacterial, 14,15,16,17 anti-viral, 18,19 anticoagulant, 20 and anti-hypertensive properties. 21 Despite of many attempts to develop and discover new structural type in the search for great and more effective antimicrobials, benzimidazoles still consider as one of the most versatile and significant type of compounds against microbes.…”