Synthesis and study of the analgesic and antiinflammatory activity of imidazo[2,1-b]thiazolium bromides

Chumakov, V. A.; Demchenko, A. M.; Красовский, А. Н.; Bukhtiarova, T. A.; Mel'nichenko, O. A.; Trinus, F. P.; Lozinskii, M. O.

doi:10.1007/bf02510093

Cited by 5 publications

(2 citation statements)

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“…Among these molecules are several fused nitrogen‐ and sulfur‐containing heterocyclic anti‐cancer agents incorporating a (benzo)thiazole fragment, [10–22] a thiadiazole ring, [23–28] or a thiadiazine unit [27–29] . The same scaffolds can be found in molecules with antibacterial, antimicrobial and antifungal properties, [22,30–35] prospective therapeutic agents used to treat asthma or chronic obstructive pulmonary disease, [36–38] molecules with anti‐inflammatory activity, [39] compounds with antidiabetic activity, [40,41] and promising therapeutics to treat Alzheimer's disease [42–44] or schizophrenia [45] …”

Section: Introductionmentioning

confidence: 99%

Oxidative Cyclization of 4‐(2‐Mercaptophenyl)‐Substituted 4H‐1,2,4‐Triazolium Species to Tricyclic Benzothiazolium Salts

Ardón-Muñoz

Bolliger

2022

Eur J Org Chem

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Herein we report a generally applicable method for the preparation of ,2,4]triazol-1-ium salts from air stable precursors. This transformation features selective deprotection of a para-methoxybenzyl protected thiol followed by CÀ H functionalization of the linked 1,2,4-triazolium salts under oxidative conditions.Using this procedure, we synthesized a variety of tricyclic thiazolium salts which contain both electron-withdrawing and electron-donating aromatic substituents as well as aliphatic substituents. Our approach also tolerates many functional groups including alkynes, alcohols, diols, amides, and polyethers.

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Section: Introductionmentioning

confidence: 99%

Oxidative Cyclization of 4‐(2‐Mercaptophenyl)‐Substituted 4H‐1,2,4‐Triazolium Species to Tricyclic Benzothiazolium Salts

Ardón-Muñoz

Bolliger

2022

Eur J Org Chem

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“…Thiazolium salts and bis-thiazolium salts have been prepared and examined as antimalarial potent agents [14]. Imidazo [2,1-b]thiazolium bromides showed analgesic and anti-inflammatory activities [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and structure confirmation of 2,4-disubstituted thiazole and 2,3,4-trisubstituted thiazole as thiazolium bromide salts

et al. 2020

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The synthesis of 4-substituted 2-(2-arylhydrazinyl)thiazol-3-ium bromides and 4-aryl-2-(substituted amino)-3-(phenylamino)thiazol-3-ium bromide derivatives in high yields from the interaction of mono-and di-substituted thiosemicarbazides with phenacyl bromide derivatives is reported. The synthesized products have been elucidated using various spectroscopic tools such as IR, NMR, and mass spectrometry. Also the structure of three of the obtained compounds have been confirmed using X-ray crystallographic analyses, which showed that compounds 2-[2-(2,4-dinitrophenyl)hydrazinyl]-4-phenylthiazol-3-ium bromide and 4-phenyl-2,3-bis(phenylamino)thiazol-3-ium bromide crystals have a monoclinic shape and belonged to space group P2 1 /c, whereas the crystals of 4-phenyl-2-(2-tosylhydrazinyl)thiazol-3-ium bromide show an orthorhombic shape with the space group Pbca

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Fused azole-thiazolines via one-pot cyclization of functionalized N-heterocyclic carbene precursors

et al. 2020

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Synthesis and study of the analgesic and antiinflammatory activity of imidazo[2,1-b]thiazolium bromides

Cited by 5 publications

References 2 publications

Oxidative Cyclization of 4‐(2‐Mercaptophenyl)‐Substituted 4H‐1,2,4‐Triazolium Species to Tricyclic Benzothiazolium Salts

Oxidative Cyclization of 4‐(2‐Mercaptophenyl)‐Substituted 4H‐1,2,4‐Triazolium Species to Tricyclic Benzothiazolium Salts

Synthesis and structure confirmation of 2,4-disubstituted thiazole and 2,3,4-trisubstituted thiazole as thiazolium bromide salts

Fused azole-thiazolines via one-pot cyclization of functionalized N-heterocyclic carbene precursors

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