Synthesis and thermal properties of nanoparticles of bioactive glasses containing silver

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

“…Bone tissue engineering is one of the most exciting future clinical applications of bioactive glasses. Both micron-sized and recently nanoscale particles [23,44,45] are considered in this application field, which includes also the fabrication of composite materials, e.g., combination of biodegradable polymers and bioactive glass [38,[46][47][48][49][50], as discussed in detail in §3.2. Bioactive silicate glasses exhibit several advantages in comparison to other bioactive ceramics, e.g., sintered hydroxyapatite, in tissue engineering applications.…”

“…The high amounts of Na 2 O and CaO, as well as the relatively high CaO/P 2 O 5 ratio make the glass surface highly reactive in physiological environments [11]. Other bioactive glass compositions developed over the years contain no sodium or have additional elements incorporated in the silicate network such as fluorine [13], magnesium [14,15], strontium [16][17][18], iron [19], silver [20][21][22][23], boron [24][25][26][27], potassium [28] or zinc [29,30]. Fabrication techniques for bioactive glasses include both traditional melting methods and sol-gel techniques [1, 3,4,10,[31][32][33], the latter are being highlighted elsewhere [34] and are not covered in this review.…”

Bioactive glass-based nanocomposites for personalized dental tissue regeneration

“…However, it is not easy to prepare bioactive glasses in nano-size scale after addition of those ions. Delben et al have developed sol-gel-derived silverdoped BGNs (~100 nm) to induce antibacterial effects by releasing silver ions 22) . In addition, the development of BGNs releasing various therapeutic ions to induce hard or nerve tissue regeneration, angiogenesis and antibacterial effects was introduced.…”

Development and Applications of Varieties of Bioactive Glass Compositions in Dental Surgery, Third Generation Tissue Engineering, Orthopaedic Surgery and as Drug Delivery System

“…High amounts of Na 2 O and CaO as well as relatively high CaO/P 2 O 5 ratio make the glass surface highly reactive in physiological environments (Hench, 1991). Other bioactive glass compositions developed over few years contain no sodium or have additional elements incorporated in the silicate network such as fluorine (Vitale-Brovarone et al, 2008), magnesium (Vitale-Brovarone et al, 2005;Vitale-Brovarone et al, 2007), strontium (Gentleman et al, 2010;Pan et al, 2010), iron (Hsi et al, 2007), silver (Balamurugan et al, 2008;Bellantone et al, 2002;Blaker et al, 2004;Delben et al, 2009), boron (Gorriti et al, 2009;Liu et al, 2009a;Liu et al, 2009b;Munukka et al, 2008), potassium (Cannillo & Sola, 2009) or zinc (Aina et al, 2009Haimi et al, 2009). Introduction of Ag 2 O into bioactive glass compositions minimize the risk of microbial contamination by antimicrobial activity of the leaching Ag + ions has been reported (Blaker et al, 2004;Saravanapavan et al, 2003).…”

“…But, bone tissue engineering is a very exotic future clinical application of these materials. Both micron-sized and nano-scale particles deployed recently (Brunner et al, 2006;Delben et al, 2009;Vollenweider et al, 2007) are considered to be the part of this application field which also include fabrication of composite materials, e.g., combination of biodegradable polymers and bioactive glass (Liu et al, 2008;Lu et al, 2003;Misra et al, 2010a;Misra et al, 2010b;Misra et al, 2008;Yang et al, 2001). Bioactive glassceramics on the other hand belong to the group of Class A bioactive materials which are characterized by both osteoconduction (growth of bone at the implant surface) and osteoinduction (activation and recruitment of osteoprogenitor cells by the material itself www.intechopen.com Biomaterials Applications for Nanomedicine 74 stimulating bone growth on the surface of the material) (Hench, 2006;Jones, 2007;Thompson & Hench, 1998).…”