Synthesis, antibacterial and antifungal activity of novel benzothiazole pyrimidine derivatives

A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

“…Some of the compounds have shown good inhibitory effect against selected cancer cell lines. Compound (82) inhibited the growth of lung and leukemia cell lines to more than 90%. Compound (83) was found as the most active member among this series of compounds which has displayed significant growth inhibition against almost all the 60 cell lines and exhibited good cytotoxic potency against the cell lines of lung, breast, ovarian, renal, CNS cancer and melanoma [125].…”

“…Compounds 39(aec) have excellent antibacterial and antifungal activities. Compounds with electron-withdrawing substituents on the aromatic ring displayed greater antibacterial activity [82].…”

Synthesis of Some Novel Thiazolo[3,2‐a]pyrimidine and Pyrimido[2,1‐b][1,3]thiazine Derivatives and their Antimicrobial Evaluation

“…They exhibited anticancer [1][2][3][4][5], antioxidant [6][7][8], antifungal [9,10], and antibacterial activities [11][12][13][14]. They exhibited anticancer [1][2][3][4][5], antioxidant [6][7][8], antifungal [9,10], and antibacterial activities [11][12][13][14].…”

Efficient synthesis and molecular docking of novel antibacterial pyrimidines and their related fused heterocyclic derivatives

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3-(Benzo[d] [1,3]dioxol-5-yl)-1-(thiophen-2-yl)prop-2-en-1-one reacted with each of thiourea and 6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one to give the corresponding pyrimidine-2(1H)-thiones. Then, these compounds reacted with the appropriate hydrazonyl chlorides in dioxane in the presence of triethylamine to afford the corresponding [1,2,4]triazolo[4,3-a]pyrimidines and their related fused pyridines.

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