Synthesis, Antibacterial and Antifungal Evaluation of Novel Pyrazoline Derivatives

Revanasiddappa, B. C.; Kumar, Mukesh; Nayak, Prashanth; Ali, Ajmal Roshan; Jisha, M. S.

doi:10.5958/0974-360x.2017.00261.x

Cited by 10 publications

(6 citation statements)

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“…With this in mind and in continuation of our work on pyrazolines [14][15][16][17] , we envisage the design and synthesis of a combination of guanicol hydrazide with heterocyclic moiety like pyrazoline, to obtain therapeutically active antibacterial and antifungal agents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antibacterial and Antifungal Evlaution of Novel Pyrazoline Derivatives

Revanasiddappa

Jisha

Kumar

et al. 2018

Dhaka Univ. J. Pharm. Sci

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A new series of chalcones (2a-j) were prepared by reacting substituted aldehydes and substituted ketones in alcohol medium in presence of NaOH. The chalcones underwent selective cyclization with guanicol hydrazide (1) in glacial acetic acid medium to yield the title compounds 1,3,5-trisubstituted pyrazolines (3a-j). The new compounds were characterized on the basis of 1H-NMR, IR and mass spectral data. All the newly synthesized compounds were evaluated for their in-vitro antibacterial and antifungal activities. Some of the tested compounds 3a and 3e showed good activity against bacterial strains and compounds 3d and 3h revealed good activity against fungal strains. Dhaka Univ. J. Pharm. Sci. 17(2): 221-226, 2018 (December)

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Section: Introductionmentioning

confidence: 99%

Synthesis, Antibacterial and Antifungal Evlaution of Novel Pyrazoline Derivatives

Revanasiddappa

Jisha

Kumar

et al. 2018

Dhaka Univ. J. Pharm. Sci

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“…The key intermediate compounds ethyl-2-arylhydrazono-3-oxobutyrate (2a-h) were prepared as per the reported procedure (Revanasiddappa et al, 2013).…”

Section: Methodsmentioning

confidence: 99%

“…Now we, hereby, reported the synthesis of novel pharmacologically active pyrazolone derivatives by the reaction of ethyl-2-arylhydrazono-3-oxobutyrate (2a-h) and naphthoic carbohydrazide (3) in glacial acetic acid as solvent. The key intermediate compounds ethyl-2-arylhydrazono-3-oxobutyrate (2a-h) were prepared as per the reported procedure (Revanasiddappa et al, 2013). The purity of the compounds was established by recrystallization technique.…”

Section: Chemistrymentioning

confidence: 99%

Synthesis and anti-depressant evaluation of novel pyrazolone derivatives

Merugumolu

Chandrashekara

2016

Bangladesh J Pharmacol

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Diazotization of substituted anilines with NaNO2 and concentrated hydro-chloric acid at 0ºC gave the diazonium chlorides. Coupling of substituted aryl diazonium chlorides with ethyl acetoacetate in methanol gave ethyl-2-aryl-hydrazono-3-oxobutyrates (2a-h). Reaction of (2a-h) with naphthoic carbohydrazide (3) gave the title compounds pyrazolone derivatives (4a-h). The newly synthesized compounds were screened for their in vivo anti-depressant activity by tail suspension test and forced swimming test. Some of the tested compounds 4f, 4g showed very good activity when compared to the standard drug imipramine. The newly synthesized compounds were characterized by physical parameters and the structures were elucidated by spectral data.Video Clips<a href="https://www.youtube.com/v/TZtb2a5u4CU">Forced swimming test</a>: 12 min 19 sec<a href="https://www.youtube.com/v/92mFRfBJgBw">Tail suspension test</a>: 8 min 5 sec

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“…Based on the above biological and pharmacological profile exhibited by chalcones and pyrazolines and in the continuing process of our work on pyrazolines [14][15][16][17] , it was thought worthwhile to synthesize a new series of pyrazoline derivatives and evaluate their antidepressant activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antidepressant Activity of Pyrazoline Derivatives

Kumar

2020

Dhaka Univ. J. Pharm. Sci

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In the present study a series of substituted pyrazolines (3a-f) has been synthesized by reacting chalcones (2a-f) and semicarbazide (1) in methanol medium. All the title compounds were assessed for their in-vivo anti-depressant activity by tail suspension test (TST) and forced swimming test (FST) methods. Compound 3a was found to exhibit moderate antidepressant activity in comparison to standard Imipramine. Newly synthesized compounds were characterized by mass (MS), 1H-NMR and infrared (IR) spectral analytical data. Dhaka Univ. J. Pharm. Sci. 19(2): 179-184, 2020 (December)

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Synthesis, Antibacterial and Antifungal Evaluation of Novel Pyrazoline Derivatives

Cited by 10 publications

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Synthesis, Antibacterial and Antifungal Evlaution of Novel Pyrazoline Derivatives

Synthesis, Antibacterial and Antifungal Evlaution of Novel Pyrazoline Derivatives

Synthesis and anti-depressant evaluation of novel pyrazolone derivatives

Synthesis and Antidepressant Activity of Pyrazoline Derivatives

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