No abstract

A new series of chalcones (3a-j) were synthesized by condensation of simple aldehydes with substituted acetophenones in presence of alkali. The resulted chalcones upon cyclization in presence of glacial acetic acid with isoniazid (INH) will yields the title compounds (4a-j). The newly synthesized compounds were assigned on the basis of IR,1H NMR, and Mass spectral data. All the final compounds were evaluated for theirin vitroantimicrobial activity.

Pyridine-3-carboxylic acid hydrazide on condensation with substituted aromatic aldehydes yielded the benzylidine-arylidine acetohydrazido pyridine derivatives, (3a-3l) which on cyclization with thioglycolic acid in presence of anhyd. Zinc chloride as catalyst afforded phenyl -3-(Nicotinyl amino)-1, 3-thiazolidin-4one derivatives (4a-4l). The structures of the newly synthesized compounds have been established on the basis of IR, MASS and 1 H NMR spectral data. These compounds have also been screened for their biological activity.

Thiazolidinone–sulfonamide hybrids emerged as promising anticancer and antitubercular agents, and their anticancer activity was confirmed by docking studies.