Synthesis and Biological Studies of some Novel Thiazolidinones

Abstract

Pyridine-3-carboxylic acid hydrazide on condensation with substituted aromatic aldehydes yielded the benzylidine-arylidine acetohydrazido pyridine derivatives, (3a-3l) which on cyclization with thioglycolic acid in presence of anhyd. Zinc chloride as catalyst afforded phenyl -3-(Nicotinyl amino)-1, 3-thiazolidin-4one derivatives (4a-4l). The structures of the newly synthesized compounds have been established on the basis of IR, MASS and 1 H NMR spectral data. These compounds have also been screened for their biological activity.

Novel 2,5-disubtituted-1,3,4-oxadiazoles with benzimidazole backbone: A new class of β-glucuronidase inhibitors and in silico studies

“…The intermediate sulfite adduct was refluxed with 4,5-dimethyl-Ophenylenediamine in DMF for 6 hours to furnish arylester 1 followed by reflux in methanolic hydrazine hydrate solution to yield hydrazide 2. Hydrazide 2 was then condensed with different aromatic carboxylic acids in POCl3 to accomplish 2,5-disubstituted-1,3,4-oxadiazoles (3a-3r) in good to excellent yields [45]. Spectral data including FT-IR, 1 H-, 13 C NMR, mass spectra and melting points of the synthesized compounds were recorded and found to be in full agreement with the proposed structures.…”

Synthesis, Evaluation and Docking Studies of Novel Formazan Derivatives as an Enoyl-Acp Reductase Inhibitors

“…This showed that the compounds were obtained in a pure state. IR and 1 Formazans have been reported to possess an attractive antimicrobial activity [6][7][8][9][10][11][12][13][14][15]. Further to confirm this, the zone of inhibition value of the all the synthesized compounds (Ia-Id) were showed good antifungal and antibacterial activity when compared to that of the standard drug.…”

“…Formazans have been studied widely owing to their ready ease of access, assorted chemical reactivity and its biological activities [4,5]. Formazans have attracted attention because of their diverse medicinal applications such as antimicrobial [6][7][8][9][10][11][12][13][14][15], (including antiviral, antifungal, antibacterial), antifertility [16], analgesic and anti-inflammatory [17][18][19][20], antitubercular [21,22], anticonvulsant [23,24], antiparkinsonian [25,26], anticancer, anti HIV [27][28][29], antiproliferative [30,31] and antihyperglycemic [32] activities.…”

Functionalized formazans: A review on recent progress in their pharmacological activities

“…The activity was compared with the known antibiotics namely Streptomycin and Griseofulvin under the same conditions. The results of the antibacterial studies indicated that the compounds 29b, e, g, i possess good activity against both the Gram positive and gram negative pathogenic organisms [84] . The rest of the compounds showed moderate activity against all the four organisms.…”

“…In another report Revanasiddappa and Subrahmanyam [84] synthesized the formazans 29a–l ( Chart 21 ) by coupling the corresponding hydrazones with the appropriate diazonium salts and assayed them in vitro for antibacterial activity against S. aureus , P. aeruginosa , E. coli and B. subtilis and antifungal activity against C. albicans and A. ringer by the cup–plate method using DMF as solvent. The activity was compared with the known antibiotics namely Streptomycin and Griseofulvin under the same conditions.…”