Synthesis, Anticancer and Antioxidant Activity of Novel Carbazole-based Thiazole Derivatives

A green synthesis and antibacterial activity of ferrocene-based thiazole derivatives in choline chloride/glycerol eutectic solvent

“…Recently, the synthesis of biologically interesting indole- or carbazolo-based thiazole hybrids have been frequently reported through molecular hybridization approach, 28–30 and these hybrids have showed potent antimicrobial, antioxidant and anticancer activities. 31–33 Prompted by these reports and with the aim of further diversifying our work to give rise to a new dimension of structural diversity as potential candidates for biological evaluation, we became very interested in the synthesis of the novel ferrocene-based indole/carbazolo-thiazole hybrids.…”

Microwave‐Assisted Synthesis of Antimicrobial Agents Containing Carbazole and Thiazole Moieties

“…The starting thiosemicarbazone, namely, 2‐((9‐ethyl‐9 H ‐carbazol‐3‐yl)methylene)‐hydrazine‐1‐carbothioamide 3 , was prepared in this context via the condensation of carbazole‐carbaldehyde derivative 1 with thiosemicarbazide 2 in ethanol in the presence of drops of HCl under two heat conditions (thermal and microwave) as portrayed in Scheme . The comparison between the yield and the reaction time from the two heating conditions revealed that microwave is more promising than thermal heating as indicated in Table .…”

“…Recently, a series of carbazole aminothiazoles were synthesized and showed potent antimicrobial activity [31]. In view of these facts and as a part of our enduring studies in the area of antimicrobial agents [32][33][34][35][36][37][38][39], we are interested in this article to synthesize biologically active hybrid pharmacophores (carbazole and thiazole) by integrating them in one molecular platform for biological evaluation.…”

Exploring the Propensities of Fluorescent Carbazole Analogs toward the Inhibition of Amyloid Aggregation in Type 2 Diabetes: An Experimental and Theoretical Endeavor

“…Carbazoles are omnipresent in the plant kingdom as carbazole alkaloids with varied biological/medicinal activities, ranging from antioxidant, anti-inflammatory, anticancer, and antidiabetic to CNS (central nervous system) activities. ,,− Interestingly, carbazole analogs with desired structures and activities can also be synthesized in the laboratory . Carbazoles with their π-conjugated aromatic rings (Figure ) can interact with the aromatic residues of the amyloidogenic proteins via π–π stacking interactions, which may induce the inhibition of self-assembly of that protein.…”