Synthesis, antimicrobial activity, and QSAR studies of furan-3-carboxamides

Zanatta, Nilo; Alves, Sydney Hartz; Coelho, Helena S.; Borchhardt, Deise M.; Machado, Pablo; Flores, Kelen M.; Silva, Fábio M. da; Spader, Tatiana; Santúrio, Jânio Morais; Bonacorso, Hélio G.; Martins, Marcos A. P.

doi:10.1016/j.bmc.2007.01.003

Cited by 65 publications

(11 citation statements)

References 45 publications

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“…The presence of electron densities in the \SO 2 NH\ group of sulfonamides contributes positively to the increase of the activity of the ligand against tested bacteria [33], but a decrease in electron densities by the coordination of donor atoms caused a decrease of activity [34]. Perhaps for this reason the nickel complex displayed good activity against gram-negative bacteria but the Co complex displayed poor activity against gram-positive bacteria, and the Cu complex displayed no activity against any bacteria or fungi.…”

Section: Electronic Spectra and Magnetic Behaviormentioning

confidence: 99%

Synthesis, characterization and antimicrobial activity of salicylaldehyde benzenesulfonylhydrazone (Hsalbsmh)and its Nickel(II), Palladium(II), Platinum(II), Copper(II), Cobalt(II) complexes

Aslan

Özcan

Karacan

2011

Inorganic Chemistry Communications

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Section: Electronic Spectra and Magnetic Behaviormentioning

confidence: 99%

Synthesis, characterization and antimicrobial activity of salicylaldehyde benzenesulfonylhydrazone (Hsalbsmh)and its Nickel(II), Palladium(II), Platinum(II), Copper(II), Cobalt(II) complexes

Aslan

Özcan

Karacan

2011

Inorganic Chemistry Communications

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“…The descriptors were selected on the basis of literature research that showed overall significance of physicochemical parameters for this kind of antimicrobial activity [34][35][36][37][38][39][40]. For descriptors calculations the CAChe Worksystem Pro (version 7.5.0.85) package was applied.…”

Section: Molecular Descriptors and Methodsmentioning

confidence: 99%

QSAR studies of a number of triazole antifungal alcohols

Nowaczyk

Modzelewska-Banachiewicz

2010

Open Chemistry

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Abstract:The activity of fungicide agents containing a quinazolinone ring was described using the quantitative structure-activity relationship (QSAR) model by applying it to data taken from literature. The title compounds exhibit two important types of activity against certain fungal pathogens, i.e. activity against yeast and activity against filamentous fungi. A correlation between both antifungal activities (e.g. FA(yst) and FA(ff)) and physicochemical parameters such as the logarithm of the n-octanol/water partition coefficient (log P), the polarizability (P), the global minimum energy (TE), the energy difference between the frontier molecular orbital (DELH) and the molar refractivity (MR), was established using multiple linear regression. The molecular descriptors of the antifungal agents were obtained by quantum chemical calculations combined with molecular modeling calculations. Statistical analysis shows that the antifungal activity depends mainly on the calculated partition coefficients, log P, of the compounds. Bi-parametric models reveal that antifungal activity relates linearly to log P and P. © Versita Sp. z o.o.

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“…The constitution of all the products was characterized using elemental analysis, FT-IR, 1 H NMR, 13 C NMR and mass spectrometry. All compounds were screened for in vitro antimicrobial activity against eight human pathogens, of which three were Gram-positive bacterial pathogens Streptococcus pneumoniae, Clostridium tetani, Bacillus subtilis, three were Gram-negative bacterial pathogens Salmonella typhi, Vibrio cholerae, Escherichia coli and two were fungal pathogens Aspergillus fumigatus and Candida albicans, using broth microdilution MIC method (NCCLS, 2002;Zanatta et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and antimicrobial evaluation of carbostyril derivatives of 1H-pyrazole

Thumar

Patel

2011

Saudi Pharmaceutical Journal

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A new series of 12 derivatives of 4-pyrazolyl-N-arylquinoline-2,5-dione (4a-l) were synthesized by one pot base catalyzed cyclocondensation reaction of 1-aryl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde (1a-c), Meldrum's acid (2) and 3-arylamino-5,5-disubstitutedcyclohex-2-enone (3a-d). All the compounds were characterized by elemental analysis, FT-IR, (1)H NMR and (13)C NMR spectral data and were screened, against six bacterial pathogens, namely Bacillus subtilis, Clostridium tetani, Streptococcus pneumoniae, Salmonella typhi, Vibrio cholerae, Escherichia coli and antifungal activity, against two fungal pathogens Aspergillus fumigatus and Candida albicans, using broth microdilution MIC (minimum inhibitory concentration) method. Some of the compounds were found to be equipotent or more potent than commercial drugs, against most of the employed strains, as evident from the screening data.

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Synthesis, antimicrobial activity, and QSAR studies of furan-3-carboxamides

Cited by 65 publications

References 45 publications

Synthesis, characterization and antimicrobial activity of salicylaldehyde benzenesulfonylhydrazone (Hsalbsmh)and its Nickel(II), Palladium(II), Platinum(II), Copper(II), Cobalt(II) complexes

Synthesis, characterization and antimicrobial activity of salicylaldehyde benzenesulfonylhydrazone (Hsalbsmh)and its Nickel(II), Palladium(II), Platinum(II), Copper(II), Cobalt(II) complexes

QSAR studies of a number of triazole antifungal alcohols

Synthesis, characterization, and antimicrobial evaluation of carbostyril derivatives of 1H-pyrazole

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