Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-(1-adamantyl)-5-substituted-1,3,4-oxadiazoles and 2-(1-adamantylamino)-5-substituted-1,3,4-thiadiazoles

Crystal structure of 2-[3,5-bis(trifluoromethyl)benzylsulfanyl]-5-(5-bromothiophen-2-yl)-1,3,4-oxadiazole, C15H7BrF6N2OS2

“…The uorine atoms of the disorderd CF 3 -group were located on a di erence Fourier map and re ned freely. chemistry as pharmacophores or auxophores possessing diverse pharmacological activities, including antibacterial [1][2][3][4][5], anticancer [6][7][8][9][10], antiviral [11][12][13], antihypertensive [14,15], anti-in ammatory [16,17] and antioxidant [18] activities. In addition, some 1,3,4-oxadiazoles are currently used as safe herbicides for crop protection [19][20][21].…”

Crystal structure of 3-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}-5-(thiophen- 2-yl)-2,3-dihydro-1,3,4-oxadiazole-2-thione, C17H17FN4OS2

“…Thus, several 1,3,4-oxadiazole derivatives were reported to possess marked chemotherapeutic activities as antibacterial, antifungal, anti-HIV and anticancer activities [1][2][3][4]. In addition, potent anti-inflammatory activity was observed for several 1,3,4-oxadiazole derivatives [4,5]. The title compound was synthesized among a series of 2-thienyl-1,3,4-oxadiazoles and related derivatives as potential antimicrobial agents [6].…”

“…Discussion 1,3,4-Oxadiazole nucleus represents the key pharmacophore of several biologically-active agents. Thus, several 1,3,4-oxadiazole derivatives were reported to possess marked chemotherapeutic activities as antibacterial, antifungal, anti-HIV and anticancer activities [1][2][3][4]. In addition, potent anti-inflammatory activity was observed for several 1,3,4-oxadiazole derivatives [4,5].…”

Crystal structure of 5-(adamantan-1-yl)-3-[(4-chloroanilino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione, C19H22ClN3OS

“…Several adamantane derivatives are currently used as e cient therapies against in uenza [3][4][5], herpes simplex [6] and HIV [7][8][9] viruses. In addition, numerous adamantane derivatives were reported to exhibit marked anticancer [10,11], antibacterial [12][13][14][15] and antifungal [16] activities. In continuation to our ongoing interest in the chemical and biological properties of adamantane derivatives, we report herein the crystal structure of the title compound which displayed potent broad spectrum antibacterial activity [9].…”