Synthesis, Antimicrobial and Cytotoxic Activities of Sulfonamidomethane Linked Heterocycles

Abstract

A new class of sulfonamidomethane pyrrolyl-oxadiazoles/thiadiazoles and pyrazolyl-oxadiazoles/ thiadiazoles was prepared from arylsulfonylaminoacetic acid hydrazides and E-cinnamic acid. The lead compounds were tested for antimicrobial and cytotoxic activities. The thiadiazole compounds having chloro substituent on the aromatic ring 4c, 8c and 10c exhibited comparable antibacterial activity against Pseudomonas aeruginosa and also antifungal activity against Penicillium chrysogenum. The styryl oxadiazole compound 3c showed appreciable cytotoxic activity on A549 lung carcinoma cells which can be used as a lead compound in the future studies.

Synthesis of novel pyrroles and fused pyrroles as antifungal and antibacterial agents

“…Pyrroles and its fused derivatives, are an important class of naturally 22,23 and synthetically [24][25][26] occurring compounds with a wide-range of biological activities; antibacterial [27][28][29] , antifungal [30][31][32][33] , antiviral [34][35][36][37][38][39] , anticancer 40,41 and anti-inflammatory 42,43 . Pyrrolnitin and fludioxonil, are two naturally secreted pyrroles, reported to bear a broad spectrum antifungal activities [44][45][46] .…”

Convenient Synthesis and Biological Activity of Mono and Diacyl 2,5‐Dimercapto‐1,3,4‐thiadiazole Derivatives

“…The most commonly reported methodology for the synthesis of this group of compounds uses N,N′ ‐diacylhydrazines which treated with diphosphorus pentasulfide or Lawesson's reagent undergo cyclization forming the desired heterocyclic arrangement. Other sources describe also exchange of oxygen atom in 1,3,4‐oxadiazoles to sulfur using thiourea , the cyclization of bithioureas , or thiosemicarbazides with another compounds containing a carbonyl group .…”