Synthesis, antimicrobial and docking study of three novel 2,4,5-triarylimidazole derivatives

Tomi, Ivan Hameed R.; Al-Daraji, Ali Hussein R.; Abdula, Ahmed Mutanabbi; Marjani, Mohammed F. Al

doi:10.1016/j.jscs.2013.03.004

Cited by 30 publications

(19 citation statements)

References 10 publications

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“…The results showed that Cl‐substituted compound was active against Klebsiella pneumonia . Br‐substituted compound exhibited good antifungal activity .…”

Section: Various Reaction Schemesmentioning

confidence: 99%

Synthesis and Applications of 2‐Substituted Imidazole and Its Derivatives: A Review

Daraji

Prajapati

Patel

2019

Journal of Heterocyclic Chem

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Imidazole and its derivatives are assigned as an exclusive and multifaceted skeleton because of having a variety of applications in medicinal and synthetic organic chemistry as well as in the field of industrial chemistry. For these perspectives, various elegant methods for imidazoles and its derivatives have been developing over the last years using different types of catalyst to improve selectivity, purity, and yield of the product. Thus, we have reviewed various synthetic routes for the formation of imidazoles and their applications from 2014 to 2016.

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“…The results showed that Cl‐substituted compound was active against Klebsiella pneumonia . Br‐substituted compound exhibited good antifungal activity .…”

Section: Various Reaction Schemesmentioning

confidence: 99%

Synthesis and Applications of 2‐Substituted Imidazole and Its Derivatives: A Review

Daraji

Prajapati

Patel

2019

Journal of Heterocyclic Chem

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“…Docking studies are computational techniques for the exploration of the possible binding modes of a ligand to a given receptor, enzyme or other binding site [21]. In this study, AutoDock 4.0 was used to evaluate the binding energy of ligands inside the known 3D structure of target enzyme.…”

Section: Molecular Dockingmentioning

confidence: 99%

Screening of Furanone in Cucurbita melo and Evaluation of its Bioactive Potential Using In Silico Studies

Singh

Sudandiradoss

Abraham

2016

Interdiscip Sci Comput Life Sci

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The work presented here attempts to screen for the presence of 4-Hydroxy-2,5-dimethyl-3(2H)-furanone in fruits and also any bioactive potential present in the fruit extracts. Curcurbita melo was selected for the study, and the fruit was crushed, filtered and extracted with ethyl acetate as the solvent. The resulting extract was subjected to disk diffusion test using Kirby Bauer method for checking its antimicrobial potential. Melon extract showed promising results against different clinical pathogens, 19-mm zone being the largest against Klebsiella pneumoniae and 17 mm against Shigella dysenteriae. GC-MS data of the melon extract confirmed the existence of furanone derivative in the extract. To evaluate the antimicrobial activity, in silico studies were performed using AutoDock 4.0 software, and topoisomerase was used as the target protein molecule for the isolated compound and 3-methyl-2-(2-oxopropyl)furan as the ligand. Further, the results were interpreted using PyMol and Ligplot plus softwares. The results confirmed the presence of molecular interactions between the protein molecule and the ligand. It can be envisaged that these interactions are responsible for the inhibitory effects of the extract .

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“…Three novel 2-[5-(4-substitutedphenyl)furan-2-yl]-4,5-diphenyl-1H -imidazole derivatives 198a-c were prepared by Abdula and co-workers in 2013 [166]. The antimicrobial screenings of these derivatives against several grampositive and gram-negative species like Candida albicans were studied using a well-diffusion method.…”

Section: Synthesis Of 245-tri-aryl-1h-imidazolesmentioning

confidence: 99%

“…Docking calculations reflected the activity trends of the compounds as new discovered hits, such as 5-(4-substituted phenyl)furan-2-carboxaldehydes 197a-c prepared by the treatment of the diazonium salts RPhN + 2 Cl − and furan-2-carboxaldehyde under cuprous chloride (Meerwein method) [167]. Then, aldehyde compounds 197a-c, benzyl and ammonium acetate mixture in refluxing glacial acetic acid, produced new 2-[5-(4-substitutedphenyl)furan-2-yl]-4,5-diphenyl-1H -imidazole derivatives 198a-c in high yields (Scheme 46) [166].…”

Section: Synthesis Of 245-tri-aryl-1h-imidazolesmentioning

confidence: 99%

Current advances in the synthesis and biological potencies of tri- and tetra-substituted 1H-imidazoles

2015

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Synthesis, antimicrobial and docking study of three novel 2,4,5-triarylimidazole derivatives

Cited by 30 publications

References 10 publications

Synthesis and Applications of 2‐Substituted Imidazole and Its Derivatives: A Review

Synthesis and Applications of 2‐Substituted Imidazole and Its Derivatives: A Review

Screening of Furanone in Cucurbita melo and Evaluation of its Bioactive Potential Using In Silico Studies

Current advances in the synthesis and biological potencies of tri- and tetra-substituted 1H-imidazoles

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