Synthesis, Antiplatelet Aggregation Activity Evaluation and 3D‐QSAR of a Series of Novel 6‐Alkylamino(Alkoxyl)‐2‐Propylthio‐8‐Azapurine Nucleosides

Abstract

A series of novel 6-alkylamino(alkoxyl)-2-propylthio-8-azapurine nucleosides were synthesized by an improved route, and the human antiplatelet aggregation activities of these new compounds were evaluated. A self-organizing molecular field analysis method was used to study the three-dimensional quantitative structure-activity relationship of these novel nucleosides. The results of the antiplatelet aggregation activity evaluation and analysis of the self-organizing molecular field analysis models through shape and electrostatic grids may provide a basis for the development of new and potent antiplatelet agents.