Synthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands

Abstract

A series of six sulfur-bridged dinuclear silver(I) thiosemicarbazone complexes were synthesized through the reaction of silver(I) nitrate with 4-phenyl-3-thiosemicarbazone derivatives together with triphenylphosphine (PPh3) (in a 1:1:2 molar ratio). Following structural characterizations using various techniques such as elemental analysis, Fourier-transform infrared (FTIR) spectroscopy, as well as 1H, 13C, 31P{1H}s, COSY, and 1H-13C nuclear magnetic resonance (NMR) spectroscopy, it was found that the thiosemicarbazone ligand exists in the form of a thione rather than thiol tautomer. Subsequently, MDA-MB-231 and MCF-7 breast cancer cell lines, as well as the HT-29 colon cancer cell lines, were used to investigate the in vitro antiproliferative activities of these complexes. In all cases, the IC50 values were in the potent micromolar range. Besides, the aforementioned complexes also had good antiplasmodial activity against chloroquine-resistant P. falciparum, as per the results of histidine-rich protein 2 (HRP2) assays and cytotoxicity evaluations of MDBK cells.

Synthesis and biological investigation of novel heterocyclic thiosemicarbazone silver (I) complexes as potent antimicrobial agents

“…Therefore, they are widely used as antibacterial agents (Isabela et al, 2013), (Rowan et al, 2006) [10,11] . The complexes demonstrate in vitro anti-proliferative activity against some human cells, such as lung cells, breast tumor cells, and colon cancer cells (Bharathi et al, 2020, Khir et al, 2021 [12,13] . They are also show antiplasmodial, cytotoxic, antifungal, anti-tuberculosis, and anticancer activity (Syahrina et al, 2019, Oliveira et al, 2019, Ashiq et al, 2020 [14][15][16] .…”