2018
DOI: 10.1186/s13065-018-0515-1
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Synthesis, biological evaluation and molecular docking studies of 6-(4-nitrophenoxy)-1H-imidazo[4,5-b]pyridine derivatives as novel antitubercular agents: future DprE1 inhibitors

Abstract: Tuberculosis is an air-borne disease, mostly affecting young adults in their productive years. Here, Ligand-based drug design approach yielded a series of 23 novel 6-(4-nitrophenoxy)-1H-imidazo[4,5-b]pyridine derivatives. The required building block of imidazopyridine was synthesized from commercially available 5,5-diaminopyridine-3-ol followed by four step sequence. Derivatives were prepared using various substituted aromatic aldehydes. All the synthesized analogues were characterized using NMR, Mass analysis… Show more

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Cited by 12 publications
(2 citation statements)
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“…The previous studies suggest that some of the molecules such as benzthiazinones against DprE1 have antibacterial activity without exhibiting TB resistance [17]. This indirectly con rms that enzyme DprE1 is a promising drug target to design new anti-TB drugs [18][19][20][21][22].…”
Section: Introductionmentioning
confidence: 82%
“…The previous studies suggest that some of the molecules such as benzthiazinones against DprE1 have antibacterial activity without exhibiting TB resistance [17]. This indirectly con rms that enzyme DprE1 is a promising drug target to design new anti-TB drugs [18][19][20][21][22].…”
Section: Introductionmentioning
confidence: 82%
“…Tuberculosis, known for a long time to be a major cause of morbidity and mortality throughout the world, has for several decades been a neglected disease in both industrialized and developing countries [82]. Gawad and Bonde [83] reported the synthesis of new compounds screened for in vitro antitubercular activity against the pathogen Mycobacterium tuberculosis (H37Rv). Four compounds (Fig.…”
Section: Fig (15) Structures Of Antibacterial Compounds and Their Mic...mentioning
confidence: 99%