Synthesis, Characterisation and Electrochemical Behaviour of Rhodium(III) Complexes Containing 1,2-Naphthoquinone-2-oxime and Formation of Imine Complexes through N−O Bond Cleavage

Liu, Xiao Xia; Wong, Wing Tak

doi:10.1002/1099-0682(200102)2001:2<511::aid-ejic511>3.0.co;2-u

Cited by 11 publications

(2 citation statements)

References 41 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In comparison to the 1 H NMR spectrum recorded (Figures 4 and S13) in DMSO-d 6 and DMSO-d 6 / H 2 O mixtures (8:2, v/v), only the peaks at 12.27 [s, 1H, H(MeOH)] and 10.70 (s, 1H, NH) ppm are absent (all the other peaks, including aromatic peaks, remain intact).This is due to deuterium from D 2 O exchanging with these exchangeable protons, resulting in their disappearance in the 1 H NMR spectrum. 91 Hence, from this overall analysis, it is confirmed that 1−3 is stable in the presence of aqueous solvent or in biological media.…”

Section: Ft-ir Spectroscopymentioning

confidence: 99%

Fluorescent Diorganotin(IV) Complexes as Anticancer Agents: Study of Cytotoxicity, Cellular Localization, and Mechanism of Cell Death

et al. 2023

View full text Add to dashboard Cite

Three luminescent mixed ligand diorganotin(IV) complexes [Sn2Ph4(L)1–3(DPA)(MeOH)Cl] (where L1 = (Z)-N-((E)-3-ethoxy-2-hydroxybenzylidene)isonicotinohydrazonic acid, L2 = (Z)-N-((E)-5-bromo-2-hydroxybenzylidene)isonicotinohydrazonic acid, L3 = (Z)-N-((E)-2-hydroxy-3-methoxybenzylidene)isonicotinohydrazonic acid, and DPA = dipicolinic acid) (1–3) were synthesized and characterized physiochemically along with the single-crystal X-ray diffraction analysis of 1 and 3. Aqueous phase stabilities of the complexes were performed with UV–vis and 1H nuclear magnetic resonance, suggesting that they are stable in aqueous/biological media. The interaction of 1–3 with DNA was evaluated through analytical methods, which supported the intercalation mode of binding. Also, the interaction of complexes with bovine serum albumin was evaluated with fluorescence quenching experiments showing static quenching. In addition, the results of partition coefficients and cellular uptake suggest that the complexes are hydrophobic and can easily enter the cells. Cytotoxic potential of 1–3 was evaluated against HeLa, HT-29 (cancerous), and NIH-3T3 (normal) cell lines. Complex 2 is the most cytotoxic of the series having IC50 4.2 ± 0.7 μM against HeLa cells. Furthermore, all the complexes showed an apoptotic cell death confirmed by acridine orange/ethidium bromide, cell cycle analysis, and Annexin V-FITC/PI double staining assays. Finally, by using live cell confocal microscopy, it was found that the compounds target the mitochondria of cancer cells and raise the reactive oxygen species level.

show abstract

Section: Ft-ir Spectroscopymentioning

confidence: 99%

Fluorescent Diorganotin(IV) Complexes as Anticancer Agents: Study of Cytotoxicity, Cellular Localization, and Mechanism of Cell Death

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The ability to coordinate and the probability to produce stable complexes increased if the ligand contains rather than one donor atom which localized on suitable position within the ligand molecule [12]. Complexes are compounds containing a central atom or ion which usually a metal with vacant orbitals (Lewis acid) surrounded by several electron donor items (Lewis bases) that are recognized as ligands [13].…”

Section: -Introductionmentioning

confidence: 99%

Synthesis, Identification of Co(II), Cu(II) and Ni(II) Complexes with A Schiff Base–Azo Ligand Derived from Imidazol Derivatives, 4- Aminoacetophenon and 4- Chloroaniline and Study Their Physical Properties and Their Thermodynamic Stabilities

Farhan¹

2019

JUBPAS

View full text Add to dashboard Cite

The complexes of Co(II), Cu(II) and Ni(II) were synthesized by using schiff base – azo as a ligand, which were prepared under this study by the reaction between the Schiff base diazonium salt and the imidazole derevitive. They were characterized by element analysis, FTIR spectroscopy and UV.VIS. spectroscopy. Their electric conductivity and magnetic features were determined. Their stepwise and overall stability constants and their thermodynamic data ( , and ) were determined. The results showed that all the complexes have paramagnetic features and all of them have good conductivity. The formula of the complexes under this paper were suggested by using the mole ratio method which lead to the formation of (1 : 2) metal : ligand formula for all the complexes. In all the complexes the coordinated sites was through N atoms of the azo groups and N atom of the imidazol ring. The suggested geometrical shapes of the complexes was the octahedral shape due to the ( d2sp3 ) hybridization. Their stepwise stability constants were determined, it was found that for all the complexes they were increased toward the addition of ligand that because of the chelate effect. Their overall stability constants were determined, it was found that for all the complexes were high that because of the chelate effect. Their thermodynamic functions ( , and ) were had negative value, that refer to good stability for the complexes and these results were satisfied with the spontaneous reaction and high stability complexes.

show abstract

Synthesis, Structure and Reactions of Organometallic Derivatives of Oximes

Абеле

Lukevics

2010

Patai's Chemistry of Functional Groups

View full text Add to dashboard Cite

Organometallic derivatives of oximes were reviewed. These derivatives were selected and presented according to the place of the metal in the periodic table. Formation and reactions of disalts of oximes of type RC(CHMR′)=NOM (R, R′ = H, alkyl, aryl) and monosalts of oximes of type RC(CHMR′)=NOR″ (R″ = alkyl, aryl, M = alkali metal) were presented. Synthesis and reactions of silicon, germanium, tin, phosphorus containing oximes were included too. Beside this, oxime metal derivatives (for example, oxime palladacycles) as valuable catalysts in organic synthesis were described. In addition, oxime metal complexes exhibit wide spectrum of biological activity. Using of technetium‐99m hexamethylpropyleneamineoxime (Ceretec TM ) and related oxime complexes in diagnosis was described. Silicon and tin oxime complexes as excellent agrochemical agents were presented. Some cobalt, platinium and silicon containing oxime ethers exhibit high antitumor and cytotoxic activity and will be perspective targets for the further investigations. Introduction Synthesis, Structure and Reactions of Organometallic Derivatives of Oximes Conclusions

show abstract

Synthesis, Characterisation and Electrochemical Behaviour of Rhodium(III) Complexes Containing 1,2-Naphthoquinone-2-oxime and Formation of Imine Complexes through N−O Bond Cleavage

Cited by 11 publications

References 41 publications

Fluorescent Diorganotin(IV) Complexes as Anticancer Agents: Study of Cytotoxicity, Cellular Localization, and Mechanism of Cell Death

Fluorescent Diorganotin(IV) Complexes as Anticancer Agents: Study of Cytotoxicity, Cellular Localization, and Mechanism of Cell Death

Synthesis, Identification of Co(II), Cu(II) and Ni(II) Complexes with A Schiff Base–Azo Ligand Derived from Imidazol Derivatives, 4- Aminoacetophenon and 4- Chloroaniline and Study Their Physical Properties and Their Thermodynamic Stabilities

Synthesis, Structure and Reactions of Organometallic Derivatives of Oximes

Contact Info

Product

Resources

About