Synthesis, characterisation, crystal structure and biological activity of metal(II) complexes with theophylline

Gacki, Michał; Kafarska, Karolina; Pietrzak, Anna; Korona-Głowniak, Izabela; Wolf, Wojciech M.

doi:10.1016/j.jscs.2018.08.006

Cited by 20 publications

(14 citation statements)

References 43 publications

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“…This work enhances our recent structural and biological studies on metal complexes with theophylline 3-5 (Scheme 2), which have been already published by us [28]. Here, we report synthesis, Fourier-transform infrared spectroscopy (FTIR) spectroscopy, thermal analysis, and antioxidant and antimicrobial activities of compounds 1-2.…”

Section: Introductionsupporting

confidence: 71%

“…Compounds 1, 2 were synthesized following procedure, as described by us in [28]. Single crystals of one suitable for X-ray structure analysis were obtained at room temperature by slow evaporation from the aqueous/ethanol (1:2 v/v) solution.…”

Section: Preparation Of Complexes and Crystallizationmentioning

confidence: 99%

“…In particular, transition metal complexes with drugs have been attracting continuously growing interest [27]. Regrettably, only a limited number of complexes with theophylline have been reported so far [28][29][30][31][32][33][34][35][36]. In most cases, the coordinating atom is N7, while structures that involve N9 and O6 are also described [32,35,36].…”

Section: Introductionmentioning

confidence: 99%

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Double Palindrome Water Chain in Cu(II) Theophylline Complex. Synthesis, Characterization, Biological Activity of Cu(II), Zn(II) Complexes with Theophylline

et al. 2020

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Two metal complexes of theophylline were synthesized. Namely, 1 with the formula [Cu(theop) 2 (H 2 O) 3 ]·2H 2 O and 2, [Zn(theop) 2 ]·H 2 O (where: theop = theophylline ion). Their properties were thoroughly investigated by the elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA) that were augmented by antimicrobial and antioxidant analyses. Their radical scavenging ability (RSA) is notably higher than that of a pure theophylline itself. Similarly to theophylline complexes already studied by us 3, [Mn(theop) 2 (H 2 O) 4 ] 4, [Co(theop) 2 (H 2 O) 4 ] and 5, [Ni(theop) 2 (H 2 O) 4 ]title compounds are inactive against Gram-negative bacteria, but they show moderate or mild activity against Gram-positive rods. The low temperature, single crystal X-ray diffraction technique determines the crystal structure of 1. Its supramolecular crystal topology is affected by the unique, double palindrome water chain that formed by two conserved and a sole coordinated water molecules. Crystal packing arrangements were characterized by fingerprint plots that were derived from the Hirshfeld surfaces (HS), as calculated for all structures in the series 1, 3, 4, 5.

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Section: Introductionsupporting

confidence: 71%

Section: Preparation Of Complexes and Crystallizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Double Palindrome Water Chain in Cu(II) Theophylline Complex. Synthesis, Characterization, Biological Activity of Cu(II), Zn(II) Complexes with Theophylline

et al. 2020

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“…A new band in all complexes appeared at 569 -573 cm -1 which referred to the coordination of metal (N-M). Furthermore, all vibration bands in the nanocomplexes shifted to lower frequency as compared with free theophylline due to hydrogen bonds of water molecules with the carbonyl and amine groups [30].…”

Section: Fourier-transform Infrared Spectroscopy (Ftir) Spectramentioning

confidence: 96%

Nanoscale Synthesis of Metal(II) Theophylline Complexes and Assessment of Their Biological Activity

Ismail¹,

Al-Bairmani²,

Abbas³

et al. 2020

Nano BioMed ENG

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Three nanocomplexes of Cu(II), Co(II), and Ni(II) with theophylline were synthesized by ultrasonic sonication method. This method was used to produce smaller and narrow-distributed nanoparticles without any aggregations. Melting point, molar conductivity, solubility, flame atomic absorption, Fourier-transform infrared spectroscopy (FTIR) and elemental analysis (C, H, N, and S) were used to identify and to suggest the structure of the synthesized nanocomplexes. The transmission electron microscopy (TEM) results exhibited that the size of nanocomplexes was in the range of 15-25 nm. The efficacy of the synthesized nanocomplexes was examined against four types of bacterial strains, Staphylococcus aureus, Bacillus subtilis (gram-positive bacteria), and Klebsiella pneumoniae, Escherichia Coli (gram-negative bacteria). The results showed that all nanocomplexes had very high susceptibility to inhibit bacterial growth, as they resulted in an inhibition zone between 98% and 100%. The copper nanocomplex gave the highest inhibition zone by 100% for each type of bacterial strains, due to the surface plasmon. Therefore, a further test for the copper nanocomplex Cu(THP) 2 (H 2 O) 2 (Cl) 2 was carried out on skin injuries of laboratory mice after it was converted into cream with vaseline and was found to have a very potent influence in healing skin injuries.

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“…Theophylline is an important bioactive constituent of tea, and it is one such natural alkaloid that has shown to own variety of bioactivities at low‐dose. It is one of the most widely prescribed drugs for the treatment of disorder in the physiological functions of the pulmonary system . At present, organic solvents are mostly used for extraction of this compound .…”

Section: Introductionmentioning

confidence: 99%

Preparation of porous aromatic framework modified graphene oxide for pipette‐tip solid‐phase extraction of theophylline in tea

2019

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A new material called as porous aromatic frameworks modified graphene oxide (PAFs‐GO) was synthesized, and it was used as an adsorbent in pipette‐tip SPE for the effective purification and enrichment of theophylline in tea sample by HPLC. The properties of PAFs‐GO were characterized by field emission SEM, FTIR, thermogravimetry analysis and Brunauer Emmett Teller N2 adsorption‐desorption analysis. The results of static adsorption and dynamic adsorption test showed PAFs‐GO had higher adsorption ability (93.25 mg/g) than graphene oxide. The LOD and LOQ of the method were 0.0141 and 0.0471 µg/mL, respectively. The acceptable method reproducibility was found as intra‐ and inter‐day precisions, yielding the RSDs <4.62%. By introducing PAFs as support skeleton, the specific surface area of GO was effectively increased, and the penetrability was improved. Studies showed that the proposed method had been successfully applied for purification and enrichment of theophylline in complex tea matrix.

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Synthesis, characterisation, crystal structure and biological activity of metal(II) complexes with theophylline

Cited by 20 publications

References 43 publications

Double Palindrome Water Chain in Cu(II) Theophylline Complex. Synthesis, Characterization, Biological Activity of Cu(II), Zn(II) Complexes with Theophylline

Double Palindrome Water Chain in Cu(II) Theophylline Complex. Synthesis, Characterization, Biological Activity of Cu(II), Zn(II) Complexes with Theophylline

Nanoscale Synthesis of Metal(II) Theophylline Complexes and Assessment of Their Biological Activity

Preparation of porous aromatic framework modified graphene oxide for pipette‐tip solid‐phase extraction of theophylline in tea

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