Synthesis, characterization and absorption study of chitosan-g-poly(acrylamide-co-itaconic acid) hydrogel

Abstract

Hydrogels are hydrophilic cross-linked polymers that can absorb water several times their weight. In this study, synthesis of hydrogel based on chitosan, acrylamide and itaconic acid is prepared via radical copolymerization studied. To study the effect of initiator concentration, time, temperature, cross-linker concentration, monomer amount and itaconic percentage on the water absorption and grafting percentage of copolymerization reaction, experimental design was performed using response surface method. The determined R 2 for the quadratic models for both grafting percentage and water absorption showed values greater than 0.9, which confirm that the model is properly fitted the obtained experimental data. The optimum conditions for maximum water absorption determined by RSM are: initiator concentration 9.51 mMol/L, time 5.27 h, temperature 79.97 °C, cross-linker concentration 42.77 mMol/L and itaconic percentage 18.42%. Synthesized hydrogel is characterized using FTIR and thermogravimetric analysis and scanning electron microscopy. The results indicate the porous structure of the hydrogel; thus, this porous natural-based hydrogel can be used in variety of applications such as medical and environmental fields as a drug carrier or water treatment application.

Using design of experiments to understand and predict polymer microcapsule core‐shell architecture

“…All dependent variables were tested for normality and subsequently fit using the following nonlinear quadratic model 25,28 where, Y i is the dependent variable (i.e., response) associated with each factor level combination, b 0 is the intercept, and b 1 ‐b 33 are the regression coefficients of the factors. X 1 , X 2 , and X 3 are the coded levels of the independent variables (i.e., factors or predictors).…”

“…All dependent variables were tested for normality and subsequently fit using the following nonlinear quadratic model 25,28…”

“…To do this, we used a design of experiments approach (DOE). DOEs are commonly used in industry to optimize formulations 25 and processes 26 . Briefly, input variables, with user defined ranges, thought to affect the desired responses are entered into a statistical software (JMP14 Pro) that outputs an experimental matrix dictating which setting for each variable to use in each experiment 27 .…”

Poly(acrylamide‐co‐acrylic acid)/chitosan semi‐interpenetrating hydrogel for pressure sensor and controlled drug release

“…Hydrogel is a hydrophilic three‐dimensional (3D) polymer network with an inherent structure similar to biological materials, whose physical and chemical properties are tunable 1,2 . Therefore, hydrogel is widely used in sensors, 3,4 drug release, 5,6 adsorption, 7‐9 agriculture, 10,11 and other fields 12,13 . The durability and stress‐bearing applications, especially high comprehensive performances of quick recovery with no residual strain, are critical for hydrogels to realize their potential applications in biological materials such as human‐made cartilages and tissues 13,14 .…”

Polymer brush‐grafted monolithic macroporous polyHIPEs obtained by surface‐initiated ARGET ATRP and heparinized for Enterovirus 71 purification

“…Polymer brush [11][12][13][14][15][16][17][18][19][20][21] is permitted to overcome this difficulty, as it is capable of immobilizing abundant functional molecules. More importantly, these flexible polymer brushes could extend into the interior of pores to form threedimensional adsorption networks in the pores for easier capture of target biomacromolecules.…”