Synthesis, characterization and anti-cancer properties of water-soluble bis(PYE) pro-ligands and derived palladium(<scp>ii</scp>) complexes

Zafar, Muhammad; Masood, Sara; Chaudhry, Gul-e-Saba; Muhammad, Tengku Sifzizul Tengku; Dalebrook, Andrew F.; Nazar, Muhammad Faizan; Malik, Fouzia Perveen; Mughal, Ehsan Ullah; Wright, L. James

doi:10.1039/c9dt01923e

Cited by 34 publications

(19 citation statements)

References 31 publications

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“…[ 49,50 ] The IC 50 values of the prepared organic ligand and its metal complexes (Table 4) are consistent with the reported values. [ 51,52 ]…”

Section: Resultsmentioning

confidence: 99%

“…[49,50] The IC 50 values of the prepared organic ligand and its metal complexes (Table 4) are consistent with the reported values. [51,52] It is obvious that certain copper complexes exhibited good cytotoxic activity as exemplified by [Cu(HL)Cl.H 2 O] and [Cu 2 (L)(Ac) 2 (H 2 O) 4 ] complexes. However, [Cu(HL) NO 3 .H 2 O] exhibited a relatively lower activity.…”

Section: In Vitro Cytotoxic Activitymentioning

confidence: 99%

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Nanometer‐sized, rod‐like, ligand‐containing tryptophan complexes: Anion influence–structural geometry–antitumor activity correlations

Elhusseiny

Hassan

Fadhil

et al. 2020

Applied Organom Chemis

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Matrix metalloproteinases (MMPs) are metal-dependent endopeptidases that are related to the initiation and progression of diseases and are involved in physiological processes such as angiogenesis, wound healing, and embryonic development. Synthetic inhibitors of MMPs are amino acid-based ligands as analyzed by the interactions between the enzyme and its natural substrate. Low production cost and low environmental toxicity of α-amino acid complexes resulted in a wide pharmacological spectrum, including the anti-inflammatory and anticonvulsant properties in addition to cytotoxic activities. These facts directed our search for the development of selective inhibitors that contain chemical entity. L-Tryptophan is a main component of proteins and is essential in human nutrition for establishing and sustaining positive nitrogen balance. Nanomaterials exhibited clinical influence in terms of delivery approaches on bioactive molecules as therapeutic and imaging contrast agents. In this article, we report the synthesis of nanometer rod-like 2,2 0-(1,3,5,7-tetraoxopyrrolo[3,4-f]isoindole-2,6(1H,3H,5H,7H)-diyl)bis(3-(1H-indol-3-yl)propanoic acid) and its metal complexes. The effect of different anions on the geometrical structures and properties of several complexes was studied. Studies indicated that most complexes exhibited dinuclear octahedral or tetrahedral topologies with MM interaction being absent, whereas mononuclear square planar or square pyramidal topologies were obtained for copper complexes containing chloride or nitrate anions. The ligand exhibited its activity solely against Bacillus subtilis. [Co 2 (L)Cl 2 (H 2 O) 2 ] complex exhibited potent activity against various species of pathogenic microorganisms. The cytotoxicity against MCF-7 cell line demonstrated that the inhibitory effect is dose dependent. [Cu(HL)Cl.H 2 O] complex exhibited an interesting cytotoxic activity in addition to copper anticancer analogues, the alternatives to cis-platin because of their biocompatibility and important roles in biological systems.

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“…[ 49,50 ] The IC 50 values of the prepared organic ligand and its metal complexes (Table 4) are consistent with the reported values. [ 51,52 ]…”

Section: Resultsmentioning

confidence: 99%

Section: In Vitro Cytotoxic Activitymentioning

confidence: 99%

Nanometer‐sized, rod‐like, ligand‐containing tryptophan complexes: Anion influence–structural geometry–antitumor activity correlations

Elhusseiny

Hassan

Fadhil

et al. 2020

Applied Organom Chemis

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“…The cells were cultured in the labtek chamber slides at a cell density of 2×10 4 cells/ chamber and incubated at 37ºC in a humidified atmosphere in the presence of 5% (v/v) CO 2 for 24hr. As previously reported (Chaudhry et al, 2019a;Zafar et al, 2019;Mahar et al, 2019) with slight modifications as in this study, the colorimetric reagent used. After treatment, the cells fixed by using 4% paraformaldehyde solution in PBS (pH 7.4) for 25 mins at 4°C.…”

Section: Determination Of Apoptotic Cell Death (Dna Fragmentation) Bymentioning

confidence: 92%

Xylocarpus Moluccensis Induces Cytotoxicity in Human Hepatocellular Carcinoma HepG2 Cell Line via Activation of the Extrinsic Pathway

Chaudhry

Sohimi

Mohamad

et al. 2021

Asian Pac J Cancer Prev

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Objective: Liver cancer is one of the most common causes of cancer death, with reduced survival rates. The development of new chemotherapeutic agents is essential to find effective cytotoxic drugs that give minimum side effects to the surrounding healthy tissues. The main objective of the present study was to evaluate the cytotoxic effects and mechanism of cell death induced by the crude and diethyl ether extract of Xylocarpus mouccensis on the human hepatocellular carcinoma cell line. Methods: The cytotoxicity activity was measured using the MTS assay. The mode of cell death determined by the apoptosis study, DNA fragmentation analysis done by using the TUNEL system. The pathway study or mechanism of apoptosis observed by study caspases 8, 9, 3/7 Glo-caspases method. Results: In this study, the methanol extracts prepared from leaf Xylocarpus mouccensis leaf produced cytotoxicity effect with IC 50 (72hr) < 30µg/ml. The IC 50 value at 72 hours exerted by diethyl ether extract of Xylocarpus moluccensis leaf was 0.22 µg/ml, which was more cytotoxic than to that of crude methanol extract. The results obtained by the colorimetric TUNEL system suggest that methanol crude extract of Xylocarpus moluccensis (leaf), diethyl ether extract of Xylocarpus moluccensis (leaf) and methanol extract of Xylocarpus granatum (bark) induced DNA fragmentation in the HepG2 cell line. Besides, the caspase-Glo assay demonstrated that diethyl ether leaf extract of Xylocarpus moluccensis triggered apoptotic cell death via activation of caspases-8, and-3/7 However, no visible activation was noticed for caspase-9. Furthermore, TLC indicates the presence of potential metabolites in an extract of Xylocarpus moluccensis. Conclusion: Thus, the present study suggests the remarkable potential of active metabolites in the extract of Xylocarpus moluccensis as a future therapeutic agent for the treatment of cancer.

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“…Negative control cells were cultured with complete medium containing 1% (v/v) DMSO. Annexin V/PI staining was performed as done previosuly (Gul-e-Saba et al, 2018;Zafar et al, 2019). Cell apoptosis was observed under ImageXpress Micro XLS Widefiled High Content Screening (HCS) (Sunnyvale, USA).…”

Section: Mts Assaymentioning

confidence: 99%

Vitex Rotundifolia Fractions Induced Apoptosis in Human Breast Cancer T-47D Cell Line via Activation of Extrinsic and Intrinsic Pathway

Chaudhry

Jan

Zafar

et al. 2019

Asian Pac J Cancer Prev

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Breast cancer is the most frequently diagnosed cancer and is common cause of death in women both in developed and developing countries. Different therapies are used to block breast cancer progression, however in developing countries, survival rates for breast cancer are still poor and it accounts for 22.9% of all cancers in women (Guerrero et al., 2017; Mohankumar et al., 2013). Current therapies for cancer such as chemotherapy, radiotherapy or immunotherapy primarily act by causing cell death in cancer cells. Therefore, inability to exert

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Synthesis, characterization and anti-cancer properties of water-soluble bis(PYE) pro-ligands and derived palladium(ii) complexes

Abstract: Water soluble bis(PYE) pro-ligands and derived Pd(ii) complexes show activity against breast cancer cells.

Cited by 34 publications

References 31 publications

Nanometer‐sized, rod‐like, ligand‐containing tryptophan complexes: Anion influence–structural geometry–antitumor activity correlations

Nanometer‐sized, rod‐like, ligand‐containing tryptophan complexes: Anion influence–structural geometry–antitumor activity correlations

Xylocarpus Moluccensis Induces Cytotoxicity in Human Hepatocellular Carcinoma HepG2 Cell Line via Activation of the Extrinsic Pathway

Vitex Rotundifolia Fractions Induced Apoptosis in Human Breast Cancer T-47D Cell Line via Activation of Extrinsic and Intrinsic Pathway

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