Synthesis, characterization and anti-fungal evaluation of Ni(II) and Cu(II) complexes with a derivative of 4-aminoantipyrine

Abstract

Transition metal complexes of Ni(II) and Cu(II) metal ions with the general stoichiometry [M(L)X]X and [M(L)SO 4 ], where M = Ni(II) and Cu(II), L = (1E)-N-((5-((E)-(2,3-dimethyl-1-phenyl-4-pyrazolineimino)methyl)thiophen-2-yl)methylene)-2,3-dimethyl-1-phenyl-4-pyrazolineamine and X = Cl − , NO 3 − and SO 4 2− , have been synthesized and characterized. The synthesized ligand and metal complexes were characterized by 1 H NMR, IR, mass spectrometry, UV-Vis spectra and EPR. In molecular modelling, the geometries of the Schiff's base and metal complexes were fully optimized with respect to the energy using the 6-31g(d,p) basis set. The nickel(II) complexes were found to have octahedral geometry, whereas the copper(II) complexes were of tetragonal geometry. The covalency factor (β) and orbital reduction factor (k) suggest the covalent nature of the complexes. To develop broad spectrum new molecules against seed-borne fungi, the minimum inhibitory concentration (MIC) of the ligand and its metal complexes was evaluated by the serial dilution method.

Promising photoluminescence optical approach for triiodothyronine hormone determination based on smart copper metal–organic framework nanoparticles

“…DTA/TGA Was performed on a sample and heating to 1000 °C under inert atmosphere we found that no thermal features observed. The residue was found to be bulk CuO (S3 and S4) which is consistent with elemental analysis …”

“…The residue was found to be bulk CuO (S3 and S4) which is consistent with elemental analysis. [30] 3.3 | Fe-SEM/EDX Field Emission Scanning Electron Microscopy (FE-SEM) in addition to element mapping by spatially resolved energy-dispersive X-ray spectroscopy (EDX) was applied for the MOF-NPs to get data about the distribution of the Cu-MOF-NPs like the shape, size, surface morphology and porosity of the MOF-NPs. The complimentary properties of these techniques give visions about the MOF-NPs through their photo physical properties, imaging and elemental analysis.…”

Synthesis, characterization, molecular docking studies and in vitro screening of new metal complexes with Schiff base as antimicrobial and antiproliferative agents

“…Antipyrine (N‐heterocyclic compound) and its derivatives exhibit a wide range of biological activities like analgesic, antibacterial, antifungal, anti‐inflammatory, antiviral, antiarrhythmic, antipyretic and antioxidant activities . Also, chromone derivatives, compounds with aromatic planar structure, have been of special interest in organic synthesis due to their biological activities such as anticonvulsant, antioxidant, antibacterial, antifungal, anticancer, anti‐HIV, antiulcer and anti‐inflammatory activities …”

Synthesis, spectroscopic characterization and DNA binding studies of Cu(II) complex of Schiff base containing benzothiazole moiety

“…Corrections for the inner filter effect were made using the equation [37]. F cor = F obsd 10 (Aex+Aem)/ 2 (1)…”

“…Schiff bases contain azomethine group which was synthesized by the condensation of primary amines and carbonyl compounds. The azomethine group present in the Schiff base is generally responsible for the various therapeutic properties [2]. Schiff base bears potential sites for biologically active compounds that are linked to intermolecular Hbonding and proton transfer equilibrium [3].…”