Synthesis, characterization and antibacterial activity of silver-doped TiO2 nanotubes

Aydın, M. Türkay Aytekin; Hoşgün, Halit L.; Dede, Alper; Güven, Kıymet

doi:10.1016/j.saa.2018.07.063

Cited by 38 publications

(9 citation statements)

References 22 publications

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“…Metal oxide NPs have been commonly synthesized by chemical and physical methods, which can produce a high size variability, defects and agglomeration and can reduce the effectiveness of their properties [7,13–14]. The use of chemical reducing agents causes the production of larger particles with extra energy consumption and commonly low stability.…”

Section: Introductionmentioning

confidence: 99%

Novel hollow titanium dioxide nanospheres with antimicrobial activity against resistant bacteria

Dicastillo

Patiño

Galotto

et al. 2019

Beilstein J. Nanotechnol.

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The search for and synthesis of new antimicrobial nanostructures is important to reduce microbial incidence that induces infectious diseases and to aid in the antibiotic resistance crisis, which are two of the most pressing issues in global public health. In this work, novel, hollow, calcined titanium dioxide nanospheres (CSTiO2) were successfully synthesized for the first time through the combination of electrospinning and atomic layer deposition techniques. Poly(vinylpyrrolidone) (PVP) electrosprayed spherical particles were double-coated with alumina and titanium dioxide, and after a calcination process, hollow nanospheres were obtained with a radius of approximately 345 nm and shell thickness of 17 nm. The structural characterization was performed using electron microscopy, and X-ray diffraction and small-angle X-ray diffraction evidenced an anatase titanium dioxide crystalline structure. Thermogravimetric analysis and Fourier-transform infrared spectroscopy studies demonstrated the absence of polymer residue after the calcination process. The antimicrobial properties of the developed CSTiO2 hollow nanospheres were evaluated against different bacteria, including resistant E. coli and S. aureus strains, and when compared to commercial TiO2 nanoparticles, CSTiO2 nanospheres exhibited superior performance. In addition, the positive effect of UV irradiation on the antimicrobial activity was demonstrated.

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Section: Introductionmentioning

confidence: 99%

Novel hollow titanium dioxide nanospheres with antimicrobial activity against resistant bacteria

Dicastillo

Patiño

Galotto

et al. 2019

Beilstein J. Nanotechnol.

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“…Metals and metal oxide nanomaterials have been widely studied for their applications in the clinical field because of their innovative size and properties. Titanium dioxide (TiO 2 ) nanotubes have been used such as for biosensors, drug delivery systems, and cancer therapy [9]. The antimicrobial activity of metals such as silver (Ag), copper, gold, titanium, and zinc, which are characterized by different properties and spectra of action, have been known for centuries [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Titanium dioxide (TiO 2 ) nanotubes have been used such as for biosensors, drug delivery systems, and cancer therapy [9]. The antimicrobial activity of metals such as silver (Ag), copper, gold, titanium, and zinc, which are characterized by different properties and spectra of action, have been known for centuries [9,10]. Aydin et al demonstrated that Ag-doped TiO 2 nanotubes could be used as an effective material that is free of antimicrobial resistance [9].…”

Section: Introductionmentioning

confidence: 99%

“…The antimicrobial activity of metals such as silver (Ag), copper, gold, titanium, and zinc, which are characterized by different properties and spectra of action, have been known for centuries [9,10]. Aydin et al demonstrated that Ag-doped TiO 2 nanotubes could be used as an effective material that is free of antimicrobial resistance [9]. Other researchers showed that TiO 2 microspheres combined with Ag particles possess antimicrobial properties, particularly versus S. aureus and E. coli , suggesting an application in dentistry, orthopedics, and other field of medicine [11,12].…”

Section: Introductionmentioning

confidence: 99%

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The Antibiofilm Effect of a Medical Device Containing TIAB on Microorganisms Associated with Surgical Site Infection

et al. 2019

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Surgical site infections (SSIs) represent the most common nosocomial infections, and surgical sutures are optimal surfaces for bacterial adhesion and biofilm formation. Staphylococcus spp., Enterococcus spp., and Escherichia coli are the most commonly isolated microorganisms. The aim of this research was to evaluate the antibiofilm activity of a medical device (MD) containing TIAB, which is a silver-nanotech patented product. The antibacterial effect was evaluated against Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212, and E. coli ATCC 25922 by assessing the minimum inhibitory concentration (MIC) by the Alamar Blue® (AB) assay. The antibiofilm effect was determined by evaluation of the minimum biofilm inhibitory concentration (MBIC) and colony-forming unit (CFU) count. Subsequently, the MD was applied on sutures exposed to the bacterial species. The antimicrobial and antibiofilm effects were evaluated by the agar diffusion test method, confocal laser scanning microscopy (CLSM), and scanning electron microscopy (SEM). The MIC was determined for S. aureus and E. faecalis at 2 mg/mL, while the MBIC was 1.5 mg/mL for S. aureus and 1 mg/mL for E. faecalis. The formation of an inhibition zone around three different treated sutures confirmed the antimicrobial activity, while the SEM and CLSM analysis performed on the MD-treated sutures underlined the presence of a few adhesive cells, which were for the most part dead. The MD showed antimicrobial and antibiofilm activities versus S. aureus and E. faecalis, but a lower efficacy against E. coli. Surgical sutures coated with the MD have the potential to reduce SSIs as well as the risk of biofilm formation post-surgery.

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“…However, nano-structured silver nanoparticles without surface functionalization/stabilization are thermodynamically unstable and are easily aggregated into large inactive particles [6]. Stabilizing NPs in the matrices of solid materials has been proved to be one of the most common and efficient strategies for protecting them against aggregations [7,8,9,10]. Among various reported solid materials, metal-organic frameworks (MOFs) have great potential owing to their highly porous structure, tunable surface properties, versatile framework functionalities and adjustable pore sizes [11].…”

Section: Introductionmentioning

confidence: 99%

Ag/H-ZIF-8 Nanocomposite as an Effective Antibacterial Agent Against Pathogenic Bacteria

Zhang

Song

et al. 2019

Nanomaterials

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Development of antimicrobial nanomaterials is one of the most attractive strategies for eliminating the major threat of pathogenic bacteria to public health. In this work, we developed a simple impregnation-reduction method for the synthesis of Ag-doped hierarchical ZIF-8 (Ag/H-ZIF-8) nanocomposite. The nanocomposite was characterized by several techniques and its antibacterial activity was investigated. Ag nanoparticles are uniformly dispersed in the porous ZIF-8 with narrow size distribution. Consequently, the resulting Ag/H-ZIF-8 nanocomposite showed significantly enhanced antibacterial activities compared to the single ZIF-8 or Ag nanoparticles. Furthermore, the composite is biocompatible, because no obvious toxicity was observed on Hepatic epithelial cells. This study offers a new approach for the design of hybrid antimicrobial nanomaterials that have great potentials in practical disinfections.

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Synthesis, characterization and antibacterial activity of silver-doped TiO2 nanotubes

Cited by 38 publications

References 22 publications

Novel hollow titanium dioxide nanospheres with antimicrobial activity against resistant bacteria

Novel hollow titanium dioxide nanospheres with antimicrobial activity against resistant bacteria

The Antibiofilm Effect of a Medical Device Containing TIAB on Microorganisms Associated with Surgical Site Infection

Ag/H-ZIF-8 Nanocomposite as an Effective Antibacterial Agent Against Pathogenic Bacteria

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