Synthesis, characterization and anticancer studies of bis(1-phenylpiperazine dithiocarbamato) Cu(II), Zn(II) and Pt(II) complexes: Crystal structures of 1-phenylpiperazine dithiocarbamato-S,S′ zinc(II) and Pt(II)

Andrew, Fartisincha P.; Ajibade, Peter A.

doi:10.1016/j.molstruc.2018.05.068

Cited by 47 publications

(12 citation statements)

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“…The molecular structure of the Zn(II) complex formed a chair-like eight-membered ring [-S-C-S-Zn] 2 comprised of two zinc(II) ions, two carbon atoms and four sulphur atoms. The Zn–Zn separation of 3.719 Å is similar to other reported dimeric zinc(II) dithiocarbamate complexes [ 44 ]. The geometry around each zinc(II) ion was tetrahedrally distorted, with S2–Z1–S3, S3–Z1–S1 and S4–Z1–S bond angles of 115.48, 112.70 and 107.68°, respectively.…”

Section: Resultssupporting

confidence: 86%

Synthesis, Crystal Structures and Anticancer Studies of Morpholinyldithiocarbamato Cu(II) and Zn(II) Complexes

et al. 2020

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Cu(II) and Zn(II) morpholinyldithiocarbamato complexes, formulated as [Cu(MphDTC)2] and [Zn(μ-MphDTC)2(MphDTC)2], where MphDTC is morpholinyldithiocarbamate were synthesized and characterized by elemental analysis, spectroscopic techniques and single-crystal X-ray crystallography. The molecular structure of the Cu(II) complex revealed a mononuclear compound in which the Cu(II) ion was bonded to two morpholinyl dithiocarbamate ligands to form a four-coordinate distorted square planar geometry. The molecular structure of the Zn(II) complex was revealed to be dinuclear, and each metal ion was bonded to two morpholinyl dithiocarbamate bidentate anions, one acting as chelating ligand, the other as a bridge between the two Zn(II) ions. The anticancer activity of the morpholinyldithiocarbamate ligand, Cu(II) and Zn(II) complexes were evaluated against renal (TK10), melanoma (UACC62) and breast (MCF7) cancer cells by a Sulforhodamine B (SRB) assay. Morpholinyldithiocarbamate was more active than the standard drug parthenolide against renal and breast cancer cell lines, and [Zn(μ-MphDTC)2(MphDTC)2] was the most active complex against breast cancer. The copper(II) complex had a comparable activity with the standard against renal and breast cancer cell lines but showed an enhanced potency against melanoma when compared to parthenolide.

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Section: Resultssupporting

confidence: 86%

Synthesis, Crystal Structures and Anticancer Studies of Morpholinyldithiocarbamato Cu(II) and Zn(II) Complexes

et al. 2020

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“…These bands are shifted to a higher frequency in the product 1 (1497 cm −1 ), presumably due to the increase in C–N double bond character as a consequence of the effective involvement of the nitrogen lone pair in resonance upon coordination of the diethylthiocarbamate ligand to the manganese ion [ 12 ] ( Supplementary Figure S1 ). This indicates that the C–N bond order lies between (C–N) single (1250–1350 cm −1 ) and (C=N) double bond (1640–1690 cm −1 ) [ 13 ]. Similarly, a shift is observed in the single band due to ν(C–S) stretching vibration from 986 cm −1 , in the ligand, to 990 cm −1 upon coordination.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Manganese Dithiocarbamate Complexes: New Evidence of Dioxygen Activation

et al. 2021

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(1) Background: Metal dithiocarbamate compounds have long been the subject of research due to their ease of formation, excellent properties and potential applications. However, manganese complexes with dithiocarbamates, to our knowledge, have never been used for medical imaging applications. With the aim of developing a new class of mononuclear manganese(II)-based agents for molecular imaging applications, we performed a specific investigation into the synthesis of mononuclear bis-substituted Mn(II) complexes with dithiocarbamate ligands. (2) Methods: Synthesis in either open or inert atmosphere at different Mn(II) to diethyldithiocarbamate molar ratios were performed and the products characterized by IR, EA, ESI-MS and XRD analysis. (3) Results: We found that only under oxygen-free atmospheric conditions the Mn(II) complex MnL2, where L = diethyldithiocarbamate ligand, is obtained, which was further observed to react with dioxygen in the solid state to form the intermediate superoxo Mn(III) complex [MnL2(η2-O2)]. The existence of the superoxo complex was revealed by mass spectroscopy, and this species was interpreted as an intermediate step in the reaction that led the bis-substituted Mn(II) complex, MnL2, to transform into the tris-substituted Mn(III) complex, MnL3. A similar result was found with the ligand L’ (= bis(N-ethoxyethyl)dithiocarbamate). (4) Conclusions: We found that in open atmosphere and in aqueous solution, only manganese(III) diethyldithiocarbamate complexes can be prepared. We report here a new example of a small-molecule Mn(II) complex that efficiently activates dioxygen in the solid state through the formation of an intermediate superoxide adduct.

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“…The interaction between the sodium cation and water molecules does not disturb the geometric conformation of the ligand [16]. The S-Na bond distances are 3.0291(7) Å, while the S-C ones are 1.7151(15) Å and 1.7390(15) Å indicating a tendency towards a double bond character of electron density in the S-C-S group [17]. The C-S-Na bond angle is 132.42(5)°, while the S-C-S bond angle is 120.40(8)°and is similar to what is observed for similar complexes.…”

Section: Discussionmentioning

confidence: 93%

Crystal structure of sodium morpholine-4-carbodithioate, (C₅H₁₂NNaO₃S₂)

Solomane

Ajibade

Omondi

2019

Zeitschrift Für Kristallographie - New Crystal Structures

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Synthesis, characterization and anticancer studies of bis(1-phenylpiperazine dithiocarbamato) Cu(II), Zn(II) and Pt(II) complexes: Crystal structures of 1-phenylpiperazine dithiocarbamato-S,S′ zinc(II) and Pt(II)

Cited by 47 publications

References 47 publications

Synthesis, Crystal Structures and Anticancer Studies of Morpholinyldithiocarbamato Cu(II) and Zn(II) Complexes

Synthesis, Crystal Structures and Anticancer Studies of Morpholinyldithiocarbamato Cu(II) and Zn(II) Complexes

Synthesis and Characterization of Manganese Dithiocarbamate Complexes: New Evidence of Dioxygen Activation

Crystal structure of sodium morpholine-4-carbodithioate, (C₅H₁₂NNaO₃S₂)

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Synthesis, characterization and anticancer studies of bis(1-phenylpiperazine dithiocarbamato) Cu(II), Zn(II) and Pt(II) complexes: Crystal structures of 1-phenylpiperazine dithiocarbamato-S,S′ zinc(II) and Pt(II)

Cited by 47 publications

References 47 publications

Synthesis, Crystal Structures and Anticancer Studies of Morpholinyldithiocarbamato Cu(II) and Zn(II) Complexes

Synthesis, Crystal Structures and Anticancer Studies of Morpholinyldithiocarbamato Cu(II) and Zn(II) Complexes

Synthesis and Characterization of Manganese Dithiocarbamate Complexes: New Evidence of Dioxygen Activation

Crystal structure of sodium morpholine-4-carbodithioate, (C5H12NNaO3S2)

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Crystal structure of sodium morpholine-4-carbodithioate, (C₅H₁₂NNaO₃S₂)